Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 845339..846134 | Replicon | chromosome |
| Accession | NZ_CP102244 | ||
| Organism | Escherichia coli O7:H15 strain ST70 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A658LKE6 |
| Locus tag | NQZ80_RS04025 | Protein ID | WP_001596171.1 |
| Coordinates | 845339..845713 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A6D0GHH4 |
| Locus tag | NQZ80_RS04030 | Protein ID | WP_071342845.1 |
| Coordinates | 845760..846134 (-) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NQZ80_RS04000 (841410) | 841410..842393 | - | 984 | WP_001366845.1 | KpsF/GutQ family sugar-phosphate isomerase | - |
| NQZ80_RS04005 (843152) | 843152..843373 | - | 222 | Protein_786 | IS110 family transposase | - |
| NQZ80_RS04010 (843715) | 843715..844557 | - | 843 | Protein_787 | DUF4942 domain-containing protein | - |
| NQZ80_RS04015 (844642) | 844642..844839 | - | 198 | WP_001596173.1 | DUF957 domain-containing protein | - |
| NQZ80_RS04020 (844851) | 844851..845342 | - | 492 | WP_148980277.1 | DUF5983 family protein | - |
| NQZ80_RS04025 (845339) | 845339..845713 | - | 375 | WP_001596171.1 | TA system toxin CbtA family protein | Toxin |
| NQZ80_RS04030 (845760) | 845760..846134 | - | 375 | WP_071342845.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| NQZ80_RS04035 (846295) | 846295..846516 | - | 222 | WP_000692323.1 | DUF987 domain-containing protein | - |
| NQZ80_RS04040 (846579) | 846579..847055 | - | 477 | WP_001186726.1 | RadC family protein | - |
| NQZ80_RS04045 (847071) | 847071..847556 | - | 486 | WP_001596167.1 | antirestriction protein | - |
| NQZ80_RS04050 (847648) | 847648..848130 | - | 483 | Protein_795 | DUF945 domain-containing protein | - |
| NQZ80_RS04055 (848254) | 848254..848487 | - | 234 | WP_001117568.1 | DUF905 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14161.14 Da Isoelectric Point: 6.7041
>T253355 WP_001596171.1 NZ_CP102244:c845713-845339 [Escherichia coli O7:H15]
MKTLPDTHVREASRCPSPVTIWQTLLARLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYELVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
MKTLPDTHVREASRCPSPVTIWQTLLARLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYELVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
Download Length: 375 bp
Antitoxin
Download Length: 125 a.a. Molecular weight: 13744.51 Da Isoelectric Point: 6.4757
>AT253355 WP_071342845.1 NZ_CP102244:c846134-845760 [Escherichia coli O7:H15]
VSDTLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLTVYPTPAPATTS
VSDTLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLTVYPTPAPATTS
Download Length: 375 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A658LKE6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6D0GHH4 |