Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 297088..297719 Replicon chromosome
Accession NZ_CP102244
Organism Escherichia coli O7:H15 strain ST70

Toxin (Protein)


Gene name hicA Uniprot ID A0A210B5N4
Locus tag NQZ80_RS01295 Protein ID WP_033560611.1
Coordinates 297088..297339 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A210B5M4
Locus tag NQZ80_RS01300 Protein ID WP_024044889.1
Coordinates 297360..297719 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ80_RS01280 (292092) 292092..293159 + 1068 WP_024043585.1 HlyD family efflux transporter periplasmic adaptor subunit -
NQZ80_RS01285 (293156) 293156..295891 + 2736 WP_024216288.1 ribosome-associated ATPase/putative transporter RbbA -
NQZ80_RS01290 (295891) 295891..297015 + 1125 WP_001318088.1 ABC transporter permease -
NQZ80_RS01295 (297088) 297088..297339 + 252 WP_033560611.1 type II toxin-antitoxin system HicA family toxin Toxin
NQZ80_RS01300 (297360) 297360..297719 + 360 WP_024044889.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NQZ80_RS01305 (297838) 297838..298239 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
NQZ80_RS01310 (298245) 298245..299051 - 807 WP_000173688.1 nickel import ATP-binding protein NikE -
NQZ80_RS01315 (299048) 299048..299812 - 765 WP_001136200.1 nickel import ATP-binding protein NikD -
NQZ80_RS01320 (299812) 299812..300645 - 834 WP_001008957.1 nickel ABC transporter permease subunit NikC -
NQZ80_RS01325 (300642) 300642..301586 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9377.84 Da        Isoelectric Point: 10.4909

>T253353 WP_033560611.1 NZ_CP102244:297088-297339 [Escherichia coli O7:H15]
MRTQVQALRKKQKNTLDQIFKSPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDW

Download         Length: 252 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13370.23 Da        Isoelectric Point: 5.1797

>AT253353 WP_024044889.1 NZ_CP102244:297360-297719 [Escherichia coli O7:H15]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYAHTEKIKT
FTLRYPESLSERLTNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A210B5N4

Antitoxin

Source ID Structure
AlphaFold DB A0A210B5M4

References