Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 159069..159681 Replicon chromosome
Accession NZ_CP102244
Organism Escherichia coli O7:H15 strain ST70

Toxin (Protein)


Gene name hicA Uniprot ID U9YXE2
Locus tag NQZ80_RS00695 Protein ID WP_000833473.1
Coordinates 159069..159254 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID L4IWR9
Locus tag NQZ80_RS00700 Protein ID WP_000499744.1
Coordinates 159271..159681 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ80_RS00680 (154586) 154586..155737 + 1152 WP_000741506.1 L-threonine dehydrogenase -
NQZ80_RS00685 (155938) 155938..157476 + 1539 WP_001469350.1 aldehyde dehydrogenase AldB -
NQZ80_RS00690 (157517) 157517..158596 - 1080 WP_000061477.1 type I restriction enzyme HsdR N-terminal domain-containing protein -
NQZ80_RS00695 (159069) 159069..159254 + 186 WP_000833473.1 type II toxin-antitoxin system HicA family toxin Toxin
NQZ80_RS00700 (159271) 159271..159681 + 411 WP_000499744.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NQZ80_RS00705 (159753) 159753..161717 - 1965 WP_024216364.1 glycoside hydrolase family 127 protein -
NQZ80_RS00710 (161728) 161728..163128 - 1401 WP_024216365.1 MFS transporter -
NQZ80_RS00715 (163354) 163354..164169 + 816 WP_000891838.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6800.89 Da        Isoelectric Point: 11.7053

>T253352 WP_000833473.1 NZ_CP102244:159069-159254 [Escherichia coli O7:H15]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15241.15 Da        Isoelectric Point: 4.5486

>AT253352 WP_000499744.1 NZ_CP102244:159271-159681 [Escherichia coli O7:H15]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YXE2

Antitoxin

Source ID Structure
AlphaFold DB L4IWR9

References