Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1238442..1239004 Replicon chromosome
Accession NZ_CP102197
Organism Schaalia odontolytica strain KHUD_008

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NQK35_RS05445 Protein ID WP_257113354.1
Coordinates 1238442..1238813 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID E6KUL9
Locus tag NQK35_RS05450 Protein ID WP_009213360.1
Coordinates 1238810..1239004 (-) Length 65 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQK35_RS05435 (NQK35_05435) 1233721..1236621 - 2901 WP_257113351.1 AAA domain-containing protein -
NQK35_RS05440 (NQK35_05440) 1236767..1237969 + 1203 WP_257113353.1 DNA recombination protein RmuC -
NQK35_RS05445 (NQK35_05445) 1238442..1238813 - 372 WP_257113354.1 type II toxin-antitoxin system VapC family toxin Toxin
NQK35_RS05450 (NQK35_05450) 1238810..1239004 - 195 WP_009213360.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NQK35_RS05455 (NQK35_05455) 1239709..1240461 + 753 Protein_1056 IS3 family transposase -
NQK35_RS05460 (NQK35_05460) 1240674..1241132 + 459 WP_246823576.1 DUF1440 domain-containing protein -
NQK35_RS05465 (NQK35_05465) 1241147..1241890 + 744 WP_257113356.1 Crp/Fnr family transcriptional regulator -
NQK35_RS05470 (NQK35_05470) 1242324..1242452 + 129 WP_257113358.1 hypothetical protein -
NQK35_RS05475 (NQK35_05475) 1242552..1243175 + 624 WP_257113359.1 transposase -
NQK35_RS05480 (NQK35_05480) 1243166..1243762 + 597 WP_257113361.1 DUF3450 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-114)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-43)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13929.16 Da        Isoelectric Point: 6.2302

>T253350 WP_257113354.1 NZ_CP102197:c1238813-1238442 [Schaalia odontolytica]
MRILVDTNVWIDHLRTTEPVLVDLLERDQVCVHQSVITELALGNLKDRLIFLGALERLLIVRNVDDQGVRHFVEERRLWG
RGLSAVDAALLASVVVTPGVSLWTRDKRLRQAARDVSVLAELD

Download         Length: 372 bp

Antitoxin


Download         Length: 65 a.a.        Molecular weight: 6844.72 Da        Isoelectric Point: 4.6895

>AT253350 WP_009213360.1 NZ_CP102197:c1239004-1238810 [Schaalia odontolytica]
MRTTVTLDDDLLARAEELTGITERSALIRDAVELLVRIETGRQLAALGGSDPGAEAAPRNRARA

Download         Length: 195 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB E6KUL9

References