Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/RelE(toxin) |
Location | 899323..899822 | Replicon | chromosome |
Accession | NC_015591 | ||
Organism | Sinorhizobium meliloti AK83 |
Toxin (Protein)
Gene name | relE | Uniprot ID | Q92YA6 |
Locus tag | SINME_RS30590 | Protein ID | WP_010967939.1 |
Coordinates | 899323..899496 (-) | Length | 58 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | A0A843ZXX9 |
Locus tag | SINME_RS40095 | Protein ID | WP_014990215.1 |
Coordinates | 899493..899822 (-) | Length | 110 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
SINME_RS30565 | 895200..895685 | - | 486 | WP_010967936.1 | YidB family protein | - |
SINME_RS30570 | 895713..895964 | - | 252 | WP_003534243.1 | GlsB/YeaQ/YmgE family stress response membrane protein | - |
SINME_RS30575 | 896559..896918 | + | 360 | WP_013845635.1 | glyoxalase/bleomycin resistance/dioxygenase family protein | - |
SINME_RS30580 | 896992..898575 | - | 1584 | WP_027990963.1 | DDE-type integrase/transposase/recombinase | - |
SINME_RS30585 | 898920..899225 | + | 306 | WP_013845638.1 | hypothetical protein | - |
SINME_RS30590 | 899323..899496 | - | 174 | WP_010967939.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
SINME_RS40095 | 899493..899822 | - | 330 | WP_014990215.1 | hypothetical protein | Antitoxin |
SINME_RS36765 | 899757..899942 | + | 186 | WP_013845639.1 | hypothetical protein | - |
SINME_RS30600 | 900183..901553 | + | 1371 | WP_013845640.1 | alpha/beta hydrolase | - |
SINME_RS36770 | 901937..902278 | + | 342 | Protein_875 | hypothetical protein | - |
SINME_RS30605 | 902262..902600 | - | 339 | WP_013845641.1 | SDR family oxidoreductase | - |
SINME_RS30610 | 902717..903160 | - | 444 | WP_010967942.1 | PACE efflux transporter | - |
SINME_RS30615 | 903252..904145 | + | 894 | WP_013845642.1 | LysR family transcriptional regulator | - |
SINME_RS36775 | 904271..904447 | - | 177 | WP_013845643.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 58 a.a. Molecular weight: 6497.32 Da Isoelectric Point: 5.7733
>T25335 WP_010967939.1 NC_015591:c899496-899323 [Sinorhizobium meliloti AK83]
MKLVWARYALDDRDAIFSYIERENPRAAVHVDEEVVSAGRPLDFPESRRPGRIAGTP
MKLVWARYALDDRDAIFSYIERENPRAAVHVDEEVVSAGRPLDFPESRRPGRIAGTP
Download Length: 174 bp
>T25335 NC_015591:c899496-899323 [Sinorhizobium meliloti AK83]
ATGAAGCTCGTCTGGGCGCGATATGCGCTTGACGATCGCGACGCCATCTTCAGCTACATCGAACGAGAGAATCCGAGGGC
GGCGGTCCACGTTGACGAGGAGGTCGTCAGCGCTGGTCGTCCGCTGGACTTTCCCGAAAGCCGCCGCCCTGGCCGGATTG
CCGGAACTCCATGA
ATGAAGCTCGTCTGGGCGCGATATGCGCTTGACGATCGCGACGCCATCTTCAGCTACATCGAACGAGAGAATCCGAGGGC
GGCGGTCCACGTTGACGAGGAGGTCGTCAGCGCTGGTCGTCCGCTGGACTTTCCCGAAAGCCGCCGCCCTGGCCGGATTG
CCGGAACTCCATGA
Antitoxin
Download Length: 110 a.a. Molecular weight: 12067.72 Da Isoelectric Point: 11.1401
>AT25335 WP_014990215.1 NC_015591:c899822-899493 [Sinorhizobium meliloti AK83]
VSERLLLIALLALGPFRASQRHTGRPALLRRGPQTAAGAVEEHFIQLRAPLWLITLGGFSHREAHDAWFRAKVLRALEDT
RPDADDADADAHFQERRAAALRKAAAGDR
VSERLLLIALLALGPFRASQRHTGRPALLRRGPQTAAGAVEEHFIQLRAPLWLITLGGFSHREAHDAWFRAKVLRALEDT
RPDADDADADAHFQERRAAALRKAAAGDR
Download Length: 330 bp
>AT25335 NC_015591:c899822-899493 [Sinorhizobium meliloti AK83]
GTGAGCGAGCGCCTTCTGCTCATCGCCCTCCTGGCCCTCGGTCCGTTCCGAGCCAGCCAGCGGCATACCGGTCGTCCTGC
TCTGCTACGGCGTGGCCCCCAAACGGCCGCCGGCGCGGTCGAGGAGCACTTCATCCAACTCCGCGCTCCGCTGTGGCTGA
TCACGCTCGGCGGTTTCAGCCACAGAGAGGCTCACGACGCTTGGTTCCGCGCCAAAGTTTTGCGGGCACTCGAGGACACT
CGACCCGATGCGGACGACGCCGACGCCGATGCGCACTTTCAAGAGCGCCGCGCCGCAGCTTTGCGCAAGGCTGCGGCGGG
TGATCGATGA
GTGAGCGAGCGCCTTCTGCTCATCGCCCTCCTGGCCCTCGGTCCGTTCCGAGCCAGCCAGCGGCATACCGGTCGTCCTGC
TCTGCTACGGCGTGGCCCCCAAACGGCCGCCGGCGCGGTCGAGGAGCACTTCATCCAACTCCGCGCTCCGCTGTGGCTGA
TCACGCTCGGCGGTTTCAGCCACAGAGAGGCTCACGACGCTTGGTTCCGCGCCAAAGTTTTGCGGGCACTCGAGGACACT
CGACCCGATGCGGACGACGCCGACGCCGATGCGCACTTTCAAGAGCGCCGCGCCGCAGCTTTGCGCAAGGCTGCGGCGGG
TGATCGATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | Q92YA6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A843ZXX9 |