Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 899323..899822 Replicon chromosome
Accession NC_015591
Organism Sinorhizobium meliloti AK83

Toxin (Protein)


Gene name relE Uniprot ID Q92YA6
Locus tag SINME_RS30590 Protein ID WP_010967939.1
Coordinates 899323..899496 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A843ZXX9
Locus tag SINME_RS40095 Protein ID WP_014990215.1
Coordinates 899493..899822 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SINME_RS30565 895200..895685 - 486 WP_010967936.1 YidB family protein -
SINME_RS30570 895713..895964 - 252 WP_003534243.1 GlsB/YeaQ/YmgE family stress response membrane protein -
SINME_RS30575 896559..896918 + 360 WP_013845635.1 glyoxalase/bleomycin resistance/dioxygenase family protein -
SINME_RS30580 896992..898575 - 1584 WP_027990963.1 DDE-type integrase/transposase/recombinase -
SINME_RS30585 898920..899225 + 306 WP_013845638.1 hypothetical protein -
SINME_RS30590 899323..899496 - 174 WP_010967939.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SINME_RS40095 899493..899822 - 330 WP_014990215.1 hypothetical protein Antitoxin
SINME_RS36765 899757..899942 + 186 WP_013845639.1 hypothetical protein -
SINME_RS30600 900183..901553 + 1371 WP_013845640.1 alpha/beta hydrolase -
SINME_RS36770 901937..902278 + 342 Protein_875 hypothetical protein -
SINME_RS30605 902262..902600 - 339 WP_013845641.1 SDR family oxidoreductase -
SINME_RS30610 902717..903160 - 444 WP_010967942.1 PACE efflux transporter -
SINME_RS30615 903252..904145 + 894 WP_013845642.1 LysR family transcriptional regulator -
SINME_RS36775 904271..904447 - 177 WP_013845643.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-69)

Antitoxin

Toxin YoeB

(5-84)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6497.32 Da        Isoelectric Point: 5.7733

>T25335 WP_010967939.1 NC_015591:c899496-899323 [Sinorhizobium meliloti AK83]
MKLVWARYALDDRDAIFSYIERENPRAAVHVDEEVVSAGRPLDFPESRRPGRIAGTP

Download         Length: 174 bp

>T25335 NC_015591:c899496-899323 [Sinorhizobium meliloti AK83]
ATGAAGCTCGTCTGGGCGCGATATGCGCTTGACGATCGCGACGCCATCTTCAGCTACATCGAACGAGAGAATCCGAGGGC
GGCGGTCCACGTTGACGAGGAGGTCGTCAGCGCTGGTCGTCCGCTGGACTTTCCCGAAAGCCGCCGCCCTGGCCGGATTG
CCGGAACTCCATGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12067.72 Da        Isoelectric Point: 11.1401

>AT25335 WP_014990215.1 NC_015591:c899822-899493 [Sinorhizobium meliloti AK83]
VSERLLLIALLALGPFRASQRHTGRPALLRRGPQTAAGAVEEHFIQLRAPLWLITLGGFSHREAHDAWFRAKVLRALEDT
RPDADDADADAHFQERRAAALRKAAAGDR

Download         Length: 330 bp

>AT25335 NC_015591:c899822-899493 [Sinorhizobium meliloti AK83]
GTGAGCGAGCGCCTTCTGCTCATCGCCCTCCTGGCCCTCGGTCCGTTCCGAGCCAGCCAGCGGCATACCGGTCGTCCTGC
TCTGCTACGGCGTGGCCCCCAAACGGCCGCCGGCGCGGTCGAGGAGCACTTCATCCAACTCCGCGCTCCGCTGTGGCTGA
TCACGCTCGGCGGTTTCAGCCACAGAGAGGCTCACGACGCTTGGTTCCGCGCCAAAGTTTTGCGGGCACTCGAGGACACT
CGACCCGATGCGGACGACGCCGACGCCGATGCGCACTTTCAAGAGCGCCGCGCCGCAGCTTTGCGCAAGGCTGCGGCGGG
TGATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q92YA6

Antitoxin

Source ID Structure
AlphaFold DB A0A843ZXX9

References