25334

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 559877..560562 Replicon chromosome
Accession NC_015591
Organism Sinorhizobium meliloti AK83

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag SINME_RS29010 Protein ID WP_017263896.1
Coordinates 559877..560296 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID F7XET8
Locus tag SINME_RS29015 Protein ID WP_013845417.1
Coordinates 560293..560562 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SINME_RS28980 555135..555724 + 590 Protein_548 hypothetical protein -
SINME_RS28985 555649..557118 - 1470 WP_013845414.1 ISNCY family transposase -
SINME_RS28990 557244..558245 - 1002 WP_013845415.1 IS30 family transposase -
SINME_RS28995 558505..558885 - 381 WP_003526626.1 transcriptional regulator -
SINME_RS29000 558903..559213 - 311 Protein_552 type II toxin-antitoxin system HigB family toxin -
SINME_RS29010 559877..560296 - 420 WP_017263896.1 type II toxin-antitoxin system VapC family toxin Toxin
SINME_RS29015 560293..560562 - 270 WP_013845417.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
SINME_RS29020 560700..561170 + 471 Protein_555 LysR family transcriptional regulator -
SINME_RS29025 561281..562156 - 876 WP_013845418.1 LysR family transcriptional regulator -
SINME_RS29035 563136..564059 - 924 WP_013845420.1 LysR family transcriptional regulator -
SINME_RS29040 564176..565045 + 870 WP_013845421.1 aldo/keto reductase family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(18-55)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14732.00 Da        Isoelectric Point: 4.8722

>T25334 WP_017263896.1 NC_015591:c560296-559877 [Sinorhizobium meliloti AK83]
VSRLYMLDTNIVSELARNPQGAVTKRIAEVGPDAICVSIITAAELRYGCAKKGSSKLLAQIETILGSMQVLALDVPADAE
YGGIRAELEAAGKPIGPNDLFIAAHACMLGAVLVTANSSEFTRVRDLKVENWLDFTPSG

Download         Length: 420 bp

>T25334 NC_015591:c560296-559877 [Sinorhizobium meliloti AK83]
GTGAGCAGGCTCTACATGCTGGACACCAATATCGTGTCCGAGCTTGCGCGAAACCCACAGGGGGCTGTCACTAAACGCAT
TGCCGAGGTAGGACCGGATGCAATCTGCGTCAGCATCATTACGGCGGCAGAGTTACGCTATGGATGCGCCAAGAAGGGAT
CATCGAAACTACTGGCGCAGATCGAGACCATTCTTGGAAGTATGCAAGTGCTTGCGCTCGATGTGCCTGCTGATGCCGAA
TACGGCGGCATCCGGGCTGAACTGGAGGCCGCTGGTAAGCCCATCGGCCCGAATGACCTGTTCATCGCCGCTCATGCCTG
TATGCTTGGAGCGGTGCTGGTAACGGCCAACAGTAGCGAGTTCACACGCGTTCGTGATCTCAAGGTCGAGAACTGGCTGG
ATTTCACTCCTTCGGGTTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10203.67 Da        Isoelectric Point: 4.4798

>AT25334 WP_013845417.1 NC_015591:c560562-560293 [Sinorhizobium meliloti AK83]
MPELRHNEPTPPREAKLFRNNRSQAVRIPADFELPGDRVMIHRDGDRLIIEPVLRKNLLEVLAGLEPLGSEDEFPDVDET
LLPVKEIDL

Download         Length: 270 bp

>AT25334 NC_015591:c560562-560293 [Sinorhizobium meliloti AK83]
ATGCCCGAACTCCGACACAACGAACCAACACCGCCAAGGGAAGCTAAGCTCTTCCGAAATAATAGAAGTCAGGCTGTACG
TATCCCCGCTGATTTTGAGCTTCCCGGCGATCGGGTGATGATCCATCGGGACGGAGATCGGCTGATAATAGAGCCGGTGC
TCCGCAAGAACTTGCTGGAGGTGCTGGCTGGTTTGGAGCCGCTCGGGTCTGAAGATGAGTTCCCCGACGTTGACGAAACC
CTGCTGCCGGTGAAGGAAATCGACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A844A3Y5

References