253337

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5301326..5301951 Replicon chromosome
Accession NZ_CP102192
Organism Klebsiella pneumoniae strain S270v

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag NQZ65_RS26105 Protein ID WP_002882817.1
Coordinates 5301326..5301709 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag NQZ65_RS26110 Protein ID WP_004150355.1
Coordinates 5301709..5301951 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ65_RS26090 (NQZ65_26095) 5298692..5299594 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
NQZ65_RS26095 (NQZ65_26100) 5299591..5300226 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
NQZ65_RS26100 (NQZ65_26105) 5300223..5301152 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
NQZ65_RS26105 (NQZ65_26110) 5301326..5301709 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
NQZ65_RS26110 (NQZ65_26115) 5301709..5301951 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
NQZ65_RS26115 (NQZ65_26120) 5302156..5303073 + 918 WP_002882812.1 alpha/beta hydrolase -
NQZ65_RS26120 (NQZ65_26125) 5303087..5304028 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
NQZ65_RS26125 (NQZ65_26130) 5304073..5304510 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
NQZ65_RS26130 (NQZ65_26135) 5304507..5305367 - 861 WP_002882807.1 virulence factor BrkB family protein -
NQZ65_RS26135 (NQZ65_26140) 5305361..5305960 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T253337 WP_002882817.1 NZ_CP102192:c5301709-5301326 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT253337 WP_004150355.1 NZ_CP102192:c5301951-5301709 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References