253335

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4819891..4820407 Replicon chromosome
Accession NZ_CP102192
Organism Klebsiella pneumoniae strain S270v

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag NQZ65_RS23795 Protein ID WP_002886902.1
Coordinates 4819891..4820175 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NQZ65_RS23800 Protein ID WP_002886901.1
Coordinates 4820165..4820407 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ65_RS23770 (NQZ65_23775) 4815375..4815638 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
NQZ65_RS23775 (NQZ65_23780) 4815768..4815941 + 174 WP_002886906.1 hypothetical protein -
NQZ65_RS23780 (NQZ65_23785) 4815944..4816687 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NQZ65_RS23785 (NQZ65_23790) 4817044..4819182 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
NQZ65_RS23790 (NQZ65_23795) 4819423..4819887 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NQZ65_RS23795 (NQZ65_23800) 4819891..4820175 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NQZ65_RS23800 (NQZ65_23805) 4820165..4820407 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NQZ65_RS23805 (NQZ65_23810) 4820485..4822395 - 1911 WP_004152270.1 PRD domain-containing protein -
NQZ65_RS23810 (NQZ65_23815) 4822418..4823572 - 1155 WP_002886900.1 lactonase family protein -
NQZ65_RS23815 (NQZ65_23820) 4823638..4824378 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T253335 WP_002886902.1 NZ_CP102192:c4820175-4819891 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT253335 WP_002886901.1 NZ_CP102192:c4820407-4820165 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References