Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2741193..2742781 Replicon chromosome
Accession NZ_CP102192
Organism Klebsiella pneumoniae strain S270v

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag NQZ65_RS13605 Protein ID WP_004199851.1
Coordinates 2741193..2742515 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag NQZ65_RS13610 Protein ID WP_002904790.1
Coordinates 2742515..2742781 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ65_RS13590 (NQZ65_13595) 2736258..2738759 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
NQZ65_RS13595 (NQZ65_13600) 2738747..2739751 + 1005 WP_004199852.1 fimbrial protein -
NQZ65_RS13600 (NQZ65_13605) 2739884..2741176 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NQZ65_RS13605 (NQZ65_13610) 2741193..2742515 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
NQZ65_RS13610 (NQZ65_13615) 2742515..2742781 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NQZ65_RS13615 (NQZ65_13620) 2743047..2743373 - 327 WP_002904788.1 hydroxyisourate hydrolase -
NQZ65_RS13620 (NQZ65_13625) 2743370..2743870 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NQZ65_RS13625 (NQZ65_13630) 2743848..2745227 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
NQZ65_RS13630 (NQZ65_13635) 2745573..2746727 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NQZ65_RS13635 (NQZ65_13640) 2746708..2747631 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - mgtC / iroE 2536187..2785147 248960


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T253332 WP_004199851.1 NZ_CP102192:c2742515-2741193 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT253332 WP_002904790.1 NZ_CP102192:c2742781-2742515 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References