253318

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 3928..4508 Replicon plasmid pS234-3
Accession NZ_CP102189
Organism Klebsiella pneumoniae strain S234

Toxin (Protein)


Gene name parE Uniprot ID A0A8J3DTL7
Locus tag NQZ63_RS28845 Protein ID WP_071177730.1
Coordinates 4194..4508 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag NQZ63_RS28840 Protein ID WP_000093040.1
Coordinates 3928..4206 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ63_RS28815 (NQZ63_28815) 1..264 - 264 Protein_0 cloacin -
NQZ63_RS28820 (NQZ63_28820) 369..1856 - 1488 WP_004178082.1 group II intron reverse transcriptase/maturase -
NQZ63_RS28825 (NQZ63_28825) 2501..2746 + 246 WP_032440458.1 hypothetical protein -
NQZ63_RS28830 (NQZ63_28830) 3020..3391 + 372 WP_001237044.1 cell envelope integrity protein TolA -
NQZ63_RS28835 (NQZ63_28835) 3388..3753 + 366 WP_072354022.1 TonB family protein -
NQZ63_RS28840 (NQZ63_28840) 3928..4206 + 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
NQZ63_RS28845 (NQZ63_28845) 4194..4508 + 315 WP_071177730.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NQZ63_RS28850 (NQZ63_28850) 4672..5100 + 429 WP_001140599.1 hypothetical protein -
NQZ63_RS28855 (NQZ63_28855) 5126..5305 + 180 WP_000165970.1 Rop family plasmid primer RNA-binding protein -
NQZ63_RS28860 (NQZ63_28860) 5332..5862 - 531 WP_071177729.1 hypothetical protein -
NQZ63_RS28865 (NQZ63_28865) 5869..6600 - 732 WP_071177728.1 MobC family replication-relaxation protein -
NQZ63_RS28870 (NQZ63_28870) 6600..8564 - 1965 WP_071177727.1 TraM recognition domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..11970 11970


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11805.73 Da        Isoelectric Point: 9.8324

>T253318 WP_071177730.1 NZ_CP102189:4194-4508 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT253318 WP_000093040.1 NZ_CP102189:3928-4206 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References