253309

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5344836..5345461 Replicon chromosome
Accession NZ_CP102186
Organism Klebsiella pneumoniae strain S234

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag NQZ63_RS26375 Protein ID WP_002882817.1
Coordinates 5344836..5345219 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag NQZ63_RS26380 Protein ID WP_004150355.1
Coordinates 5345219..5345461 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ63_RS26360 (NQZ63_26360) 5342202..5343104 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
NQZ63_RS26365 (NQZ63_26365) 5343101..5343736 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
NQZ63_RS26370 (NQZ63_26370) 5343733..5344662 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
NQZ63_RS26375 (NQZ63_26375) 5344836..5345219 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
NQZ63_RS26380 (NQZ63_26380) 5345219..5345461 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
NQZ63_RS26385 (NQZ63_26385) 5345666..5346583 + 918 WP_002882812.1 alpha/beta hydrolase -
NQZ63_RS26390 (NQZ63_26390) 5346597..5347538 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
NQZ63_RS26395 (NQZ63_26395) 5347583..5348020 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
NQZ63_RS26400 (NQZ63_26400) 5348017..5348877 - 861 WP_002882807.1 virulence factor BrkB family protein -
NQZ63_RS26405 (NQZ63_26405) 5348871..5349470 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T253309 WP_002882817.1 NZ_CP102186:c5345219-5344836 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT253309 WP_004150355.1 NZ_CP102186:c5345461-5345219 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References