253308

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 5030897..5032578 Replicon chromosome
Accession NZ_CP102186
Organism Klebsiella pneumoniae strain S234

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag NQZ63_RS24900 Protein ID WP_002885155.1
Coordinates 5030897..5031814 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag NQZ63_RS24905 Protein ID WP_004151732.1
Coordinates 5031820..5032578 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ63_RS24880 (NQZ63_24880) 5026203..5027723 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
NQZ63_RS24885 (NQZ63_24885) 5027720..5028718 + 999 WP_002885172.1 ribose ABC transporter permease -
NQZ63_RS24890 (NQZ63_24890) 5028749..5029690 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
NQZ63_RS24895 (NQZ63_24895) 5029765..5030772 + 1008 WP_004151731.1 carbohydrate kinase family protein -
NQZ63_RS24900 (NQZ63_24900) 5030897..5031814 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
NQZ63_RS24905 (NQZ63_24905) 5031820..5032578 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
NQZ63_RS24910 (NQZ63_24910) 5032664..5033392 - 729 WP_002885152.1 response regulator transcription factor -
NQZ63_RS24915 (NQZ63_24915) 5033665..5035812 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
NQZ63_RS24920 (NQZ63_24920) 5036042..5036728 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T253308 WP_002885155.1 NZ_CP102186:c5031814-5030897 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT253308 WP_004151732.1 NZ_CP102186:c5032578-5031820 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References