253307

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4874713..4875229 Replicon chromosome
Accession NZ_CP102186
Organism Klebsiella pneumoniae strain S234

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag NQZ63_RS24100 Protein ID WP_002886902.1
Coordinates 4874713..4874997 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NQZ63_RS24105 Protein ID WP_002886901.1
Coordinates 4874987..4875229 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ63_RS24075 (NQZ63_24075) 4870197..4870460 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
NQZ63_RS24080 (NQZ63_24080) 4870590..4870763 + 174 WP_002886906.1 hypothetical protein -
NQZ63_RS24085 (NQZ63_24085) 4870766..4871509 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NQZ63_RS24090 (NQZ63_24090) 4871866..4874004 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
NQZ63_RS24095 (NQZ63_24095) 4874245..4874709 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NQZ63_RS24100 (NQZ63_24100) 4874713..4874997 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NQZ63_RS24105 (NQZ63_24105) 4874987..4875229 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NQZ63_RS24110 (NQZ63_24110) 4875307..4877217 - 1911 WP_004152270.1 PRD domain-containing protein -
NQZ63_RS24115 (NQZ63_24115) 4877240..4878394 - 1155 WP_002886900.1 lactonase family protein -
NQZ63_RS24120 (NQZ63_24120) 4878460..4879200 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T253307 WP_002886902.1 NZ_CP102186:c4874997-4874713 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT253307 WP_002886901.1 NZ_CP102186:c4875229-4874987 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References