253306

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4773734..4774544 Replicon chromosome
Accession NZ_CP102186
Organism Klebsiella pneumoniae strain S234

Toxin (Protein)


Gene name KacT Uniprot ID A0A0H3GMP0
Locus tag NQZ63_RS23620 Protein ID WP_002887280.1
Coordinates 4773734..4774267 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag NQZ63_RS23625 Protein ID WP_002887278.1
Coordinates 4774278..4774544 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ63_RS23615 (NQZ63_23615) 4772565..4773686 + 1122 WP_002887282.1 cupin domain-containing protein -
NQZ63_RS23620 (NQZ63_23620) 4773734..4774267 - 534 WP_002887280.1 type II toxin-antitoxin system toxin KacT Toxin
NQZ63_RS23625 (NQZ63_23625) 4774278..4774544 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
NQZ63_RS23630 (NQZ63_23630) 4774647..4776080 - 1434 WP_002887275.1 Cu(+)/Ag(+) sensor histidine kinase -
NQZ63_RS23635 (NQZ63_23635) 4776070..4776753 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
NQZ63_RS23640 (NQZ63_23640) 4776925..4778310 + 1386 WP_002887267.1 efflux transporter outer membrane subunit -
NQZ63_RS23645 (NQZ63_23645) 4778328..4778672 + 345 WP_002887266.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19838.70 Da        Isoelectric Point: 5.2614

>T253306 WP_002887280.1 NZ_CP102186:c4774267-4773734 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHVMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT253306 WP_002887278.1 NZ_CP102186:c4774544-4774278 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5ZGN
PDB 5XUN

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLZ1

References