253304

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2729272..2730860 Replicon chromosome
Accession NZ_CP102186
Organism Klebsiella pneumoniae strain S234

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag NQZ63_RS13530 Protein ID WP_004199851.1
Coordinates 2729272..2730594 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag NQZ63_RS13535 Protein ID WP_002904790.1
Coordinates 2730594..2730860 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ63_RS13515 (NQZ63_13515) 2724337..2726838 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
NQZ63_RS13520 (NQZ63_13520) 2726826..2727830 + 1005 WP_004199852.1 fimbrial protein -
NQZ63_RS13525 (NQZ63_13525) 2727963..2729255 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NQZ63_RS13530 (NQZ63_13530) 2729272..2730594 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
NQZ63_RS13535 (NQZ63_13535) 2730594..2730860 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NQZ63_RS13540 (NQZ63_13540) 2731126..2731452 - 327 WP_002904788.1 hydroxyisourate hydrolase -
NQZ63_RS13545 (NQZ63_13545) 2731449..2731949 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NQZ63_RS13550 (NQZ63_13550) 2731927..2733306 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
NQZ63_RS13555 (NQZ63_13555) 2733652..2734806 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NQZ63_RS13560 (NQZ63_13560) 2734787..2735710 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T253304 WP_004199851.1 NZ_CP102186:c2730594-2729272 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT253304 WP_002904790.1 NZ_CP102186:c2730860-2730594 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References