Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 3503170..3503803 Replicon chromosome
Accession NZ_CP102182
Organism Ralstonia solanacearum strain Wj644

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NQ322_RS16705 Protein ID WP_021155142.1
Coordinates 3503170..3503583 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q8XUX7
Locus tag NQ322_RS16710 Protein ID WP_011002949.1
Coordinates 3503570..3503803 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQ322_RS16685 3498548..3500284 + 1737 WP_016725176.1 ABC transporter substrate-binding protein -
NQ322_RS16690 3500446..3501942 + 1497 WP_016725175.1 glycerol kinase GlpK -
NQ322_RS16695 3502007..3502378 - 372 WP_016725174.1 hypothetical protein -
NQ322_RS16700 3502569..3503195 + 627 WP_016725173.1 DUF1415 domain-containing protein -
NQ322_RS16705 3503170..3503583 - 414 WP_021155142.1 PIN domain-containing protein Toxin
NQ322_RS16710 3503570..3503803 - 234 WP_011002949.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
NQ322_RS16715 3503860..3505467 - 1608 WP_020832850.1 glucan biosynthesis protein -
NQ322_RS16720 3505662..3506912 + 1251 WP_096761512.1 AGE family epimerase/isomerase -
NQ322_RS16725 3506920..3508215 + 1296 WP_011002952.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-116)

Antitoxin

SpoVT-AbrB domain

(5-37)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15117.45 Da        Isoelectric Point: 5.5348

>T253295 WP_021155142.1 NZ_CP102182:c3503583-3503170 [Ralstonia solanacearum]
MPATEAFFDSNVVLYLLSADTAKADATETLLMTGGVVSVQVLNETTHVMRRKLAMPWHAIETVQEAVRAQCRVEPLTLET
HDLGRRIAERYGLSVYDALIVAAALLAGCNVLYSEDMQHGLVIEQHLRIVNPFPARA

Download         Length: 414 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8790.98 Da        Isoelectric Point: 8.7287

>AT253295 WP_011002949.1 NZ_CP102182:c3503803-3503570 [Ralstonia solanacearum]
MQVSKWGNSLAIRLPAAVVEALQLHEGDDVEVVIAGERSFGVRRKRAARELFDRIHQYRGKLPADFIFERDQANARD

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A223GR76

References