Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1777436..1779031 Replicon chromosome
Accession NZ_CP102182
Organism Ralstonia solanacearum strain Wj644

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NQ322_RS08645 Protein ID WP_086706272.1
Coordinates 1777436..1778773 (-) Length 446 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0S4UDK3
Locus tag NQ322_RS08650 Protein ID WP_016725279.1
Coordinates 1778777..1779031 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQ322_RS08620 1773091..1773831 + 741 WP_011001390.1 protocatechuate 3,4-dioxygenase subunit beta -
NQ322_RS08625 1773828..1774526 + 699 WP_016725453.1 protocatechuate 3,4-dioxygenase subunit alpha -
NQ322_RS08630 1774674..1775270 + 597 WP_016727240.1 RNA 2',3'-cyclic phosphodiesterase -
NQ322_RS08635 1775283..1776011 - 729 WP_021155798.1 DsbA family protein -
NQ322_RS08640 1776237..1777439 - 1203 WP_023470034.1 MFS transporter -
NQ322_RS08645 1777436..1778773 - 1338 WP_086706272.1 type II toxin-antitoxin system HipA family toxin Toxin
NQ322_RS08650 1778777..1779031 - 255 WP_016725279.1 helix-turn-helix transcriptional regulator Antitoxin
NQ322_RS08655 1779135..1779974 - 840 WP_011001397.1 oxaloacetate decarboxylase -
NQ322_RS08660 1780001..1780120 - 120 Protein_1701 2-hydroxychromene-2-carboxylate isomerase -
NQ322_RS08665 1780292..1780930 + 639 WP_020831956.1 7-carboxy-7-deazaguanine synthase -
NQ322_RS08670 1780998..1781474 + 477 WP_011001399.1 6-carboxytetrahydropterin synthase QueD -
NQ322_RS08675 1781494..1782045 + 552 WP_016727233.1 tRNA adenosine(34) deaminase TadA -
NQ322_RS08680 1782042..1782968 + 927 WP_016727232.1 muramoyltetrapeptide carboxypeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-107)

Antitoxin

Transcription regulator, HipB-like

(10-66)


Sequences

Toxin        


Download         Length: 446 a.a.        Molecular weight: 48754.78 Da        Isoelectric Point: 6.7232

>T253294 WP_086706272.1 NZ_CP102182:c1778773-1777436 [Ralstonia solanacearum]
MAHPELHLWMNGEHVGIWTASRAGVPILRYDDGWLRSPNMRPLSLSLPIPAGVPELRGQVVDDYFDNLLPEAQPIRERVR
RRFGLASTDAAELLAAIGRDCVGAVQLLPPGMAPTGYDRIDSEPLTDSQVDTLLRNLTATPALGEDAGDPDAFRISIAGA
QEKTALLRIGDAWHRPLGATPTTHILKLPLGLIGNIRADMQDSVDNEWLCAQLLAAWGLEVARTEIARFGTSKVLAVERF
DRRWMPGNAWIARLPQEDFCQATGTPAHRKYENDGGPGMRACLDLLSASEHAIDDKRRFVLAQLAFWLLAATDGHAKNFS
LAIGRGGRFRMTPLYDVLSVWPIMGDGPNQLSPYRARLAMALRGKNAHARLADIHVRHWQALAAQSGVPDAFAGMQALVE
RVPAGLERVEAILPPDFSGRVWSSVRTGVLAQAERFLNELASVTP

Download         Length: 1338 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8754.07 Da        Isoelectric Point: 10.4693

>AT253294 WP_016725279.1 NZ_CP102182:c1779031-1778777 [Ralstonia solanacearum]
MESLLSSAPQLSAHLKSLRKARGLTQAQLGALLGVSQNRIADIEKDPGAVGFEQLLRILHALGAQLTLRTSAPAGTPSAA
PADW

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0S4UDK3

References