Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3569660..3571255 Replicon chromosome
Accession NZ_CP102181
Organism Ralstonia solanacearum strain Bs715

Toxin (Protein)


Gene name hipA Uniprot ID A0A0S4UDK5
Locus tag NQ321_RS25120 Protein ID WP_069079583.1
Coordinates 3569660..3570997 (-) Length 446 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0S4UDK3
Locus tag NQ321_RS25125 Protein ID WP_016725279.1
Coordinates 3571001..3571255 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQ321_RS25095 3565315..3566055 + 741 WP_011001390.1 protocatechuate 3,4-dioxygenase subunit beta -
NQ321_RS25100 3566052..3566750 + 699 WP_016725453.1 protocatechuate 3,4-dioxygenase subunit alpha -
NQ321_RS25105 3566898..3567494 + 597 WP_016725451.1 RNA 2',3'-cyclic phosphodiesterase -
NQ321_RS25110 3567507..3568235 - 729 WP_011001393.1 DsbA family protein -
NQ321_RS25115 3568461..3569663 - 1203 WP_064047701.1 MFS transporter -
NQ321_RS25120 3569660..3570997 - 1338 WP_069079583.1 type II toxin-antitoxin system HipA family toxin Toxin
NQ321_RS25125 3571001..3571255 - 255 WP_016725279.1 helix-turn-helix transcriptional regulator Antitoxin
NQ321_RS25130 3571359..3572198 - 840 WP_016725278.1 oxaloacetate decarboxylase -
NQ321_RS25135 3572516..3573154 + 639 WP_020831956.1 7-carboxy-7-deazaguanine synthase -
NQ321_RS25140 3573222..3573698 + 477 WP_011001399.1 6-carboxytetrahydropterin synthase QueD -
NQ321_RS25145 3573718..3574269 + 552 WP_016727233.1 tRNA adenosine(34) deaminase TadA -
NQ321_RS25150 3574266..3575192 + 927 WP_016727232.1 muramoyltetrapeptide carboxypeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-107)

Antitoxin

Transcription regulator, HipB-like

(10-66)


Sequences

Toxin        


Download         Length: 446 a.a.        Molecular weight: 48724.75 Da        Isoelectric Point: 6.7232

>T253293 WP_069079583.1 NZ_CP102181:c3570997-3569660 [Ralstonia solanacearum]
MAHPELHLWMNGEHVGIWTASRAGVPILRYDDGWLRSPNMRPLSLSLPIPAGVPELRGQVVDDYFDNLLPEAQPIRERVR
RRFGLASTDAAELLAAIGRDCVGAVQLLPPGMAPTGYDRIDSEPLTDSQVDTLLRNLTATPALGEDAGDPDAFRISIAGA
QEKTALLRIGDAWHRPLGATPTTHILKLPLGLIGNIRADMQDSVDNEWLCAQLLAAWGLEVARTEIARFGASKVLAVERF
DRRWMPGNAWIARLPQEDFCQATGTPAHRKYENDGGPGMRACLDLLSASEHAIDDKRRFVLAQLAFWLLAATDGHAKNFS
LAIGRGGRFRMTPLYDVLSVWPIMGDGPNQLSPYRARLAMALRGKNAHARLADIHVRHWQALAAQSGVPDAFAGMQALVE
RVPAGLERVEAILPPDFSGRVWSSVRTGVLAQAERFLNELASVTP

Download         Length: 1338 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8754.07 Da        Isoelectric Point: 10.4693

>AT253293 WP_016725279.1 NZ_CP102181:c3571255-3571001 [Ralstonia solanacearum]
MESLLSSAPQLSAHLKSLRKARGLTQAQLGALLGVSQNRIADIEKDPGAVGFEQLLRILHALGAQLTLRTSAPAGTPSAA
PADW

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0S4UDK5

Antitoxin

Source ID Structure
AlphaFold DB A0A0S4UDK3

References