Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 1387587..1388220 Replicon chromosome
Accession NZ_CP102181
Organism Ralstonia solanacearum strain Bs715

Toxin (Protein)


Gene name vapC Uniprot ID M4UIT8
Locus tag NQ321_RS14740 Protein ID WP_016725172.1
Coordinates 1387587..1388000 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q8XUX7
Locus tag NQ321_RS14745 Protein ID WP_011002949.1
Coordinates 1387987..1388220 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQ321_RS14720 1382965..1384701 + 1737 WP_118887843.1 ABC transporter substrate-binding protein -
NQ321_RS14725 1384863..1386359 + 1497 WP_016725175.1 glycerol kinase GlpK -
NQ321_RS14730 1386424..1386795 - 372 WP_016725174.1 hypothetical protein -
NQ321_RS14735 1386986..1387612 + 627 WP_016725173.1 DUF1415 domain-containing protein -
NQ321_RS14740 1387587..1388000 - 414 WP_016725172.1 PIN domain-containing protein Toxin
NQ321_RS14745 1387987..1388220 - 234 WP_011002949.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
NQ321_RS14750 1388277..1389884 - 1608 WP_020832850.1 glucan biosynthesis protein -
NQ321_RS14755 1390097..1391329 + 1233 WP_021155141.1 AGE family epimerase/isomerase -
NQ321_RS14760 1391337..1392632 + 1296 WP_011002952.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-116)

Antitoxin

SpoVT-AbrB domain

(5-37)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15087.42 Da        Isoelectric Point: 5.5348

>T253292 WP_016725172.1 NZ_CP102181:c1388000-1387587 [Ralstonia solanacearum]
MPATEAFFDSNVVLYLLSADTAKADAAETLLMTGGVVSVQVLNETTHVMRRKLAMPWHAIETVQEAVRAQCRVEPLTLET
HDLGRRIAERYGLSVYDALIVAAALLAGCNVLYSEDMQHGLVIEQHLRIVNPFPARA

Download         Length: 414 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8790.98 Da        Isoelectric Point: 8.7287

>AT253292 WP_011002949.1 NZ_CP102181:c1388220-1387987 [Ralstonia solanacearum]
MQVSKWGNSLAIRLPAAVVEALQLHEGDDVEVVIAGERSFGVRRKRAARELFDRIHQYRGKLPADFIFERDQANARD

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M4UIT8

Antitoxin

Source ID Structure
AlphaFold DB A0A223GR76

References