Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 298698..299374 Replicon chromosome
Accession NZ_CP102176
Organism Pseudomonas mediterranea strain B21-060

Toxin (Protein)


Gene name hicA Uniprot ID A0A6I6QGT7
Locus tag LOY71_RS01275 Protein ID WP_047699956.1
Coordinates 298698..298880 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A6I6Q5Q0
Locus tag LOY71_RS01280 Protein ID WP_047700163.1
Coordinates 298973..299374 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY71_RS01260 (LOY71_01260) 294846..296807 + 1962 WP_193754011.1 choline transporter BetT -
LOY71_RS01265 (LOY71_01265) 296819..297559 - 741 WP_055127576.1 SDR family oxidoreductase -
LOY71_RS01270 (LOY71_01270) 297677..298567 + 891 WP_047699958.1 LysR family transcriptional regulator -
LOY71_RS01275 (LOY71_01275) 298698..298880 + 183 WP_047699956.1 type II toxin-antitoxin system HicA family toxin Toxin
LOY71_RS01280 (LOY71_01280) 298973..299374 + 402 WP_047700163.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOY71_RS01285 (LOY71_01285) 299437..300474 + 1038 WP_055127575.1 L-glyceraldehyde 3-phosphate reductase -
LOY71_RS01290 (LOY71_01290) 300601..301443 - 843 WP_055127574.1 taurine dioxygenase -
LOY71_RS01295 (LOY71_01295) 301492..302331 - 840 WP_055127573.1 taurine ABC transporter permease TauC -
LOY71_RS01300 (LOY71_01300) 302328..303122 - 795 WP_047699950.1 taurine ABC transporter ATP-binding subunit -
LOY71_RS01305 (LOY71_01305) 303151..304128 - 978 WP_055127572.1 taurine ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6897.99 Da        Isoelectric Point: 10.7459

>T253276 WP_047699956.1 NZ_CP102176:298698-298880 [Pseudomonas mediterranea]
MRSREMIRKIEEDGWYLVAVKGSHHQYKHSVKTGRVTIKHPDSDLPRGTINSILKQAGLK

Download         Length: 183 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14710.45 Da        Isoelectric Point: 4.5232

>AT253276 WP_047700163.1 NZ_CP102176:298973-299374 [Pseudomonas mediterranea]
MKFPVVLHKDADSEYGVTVPDVPGCFSAGSTVAQAFENVKEALSLHYEGLVADGEPLPQIHEVDDHLDNPEYAGGIWGVV
EFDVTPYFGKSVRFNATLPEQLLERIDQTVRKDQRYRSRSGFLAAAALRELST

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I6QGT7

Antitoxin

Source ID Structure
AlphaFold DB A0A6I6Q5Q0

References