Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4771178..4772436 Replicon chromosome
Accession NZ_CP102174
Organism Pseudomonas aeruginosa strain PA5083

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag NQ602_RS22245 Protein ID WP_003086331.1
Coordinates 4771178..4771933 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag NQ602_RS22250 Protein ID WP_003086329.1
Coordinates 4772068..4772436 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQ602_RS22235 (NQ602_22235) 4766349..4768892 + 2544 WP_003086335.1 acyl-homoserine-lactone acylase QuiP -
NQ602_RS22240 (NQ602_22240) 4769047..4770408 - 1362 WP_003081943.1 DNA recombination protein RmuC -
NQ602_RS22245 (NQ602_22245) 4771178..4771933 - 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
NQ602_RS22250 (NQ602_22250) 4772068..4772436 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
NQ602_RS22255 (NQ602_22255) 4772509..4773795 - 1287 WP_003086327.1 FAD-binding oxidoreductase -
NQ602_RS22260 (NQ602_22260) 4773851..4775440 - 1590 WP_003123191.1 aldehyde dehydrogenase family protein -
NQ602_RS22265 (NQ602_22265) 4775519..4775995 + 477 WP_003086322.1 hypothetical protein -
NQ602_RS22270 (NQ602_22270) 4775998..4776273 - 276 WP_023098713.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T253271 WP_003086331.1 NZ_CP102174:c4771933-4771178 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT253271 WP_003086329.1 NZ_CP102174:c4772436-4772068 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References