253269

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3259037..3260258 Replicon chromosome
Accession NZ_CP102174
Organism Pseudomonas aeruginosa strain PA5083

Toxin (Protein)


Gene name vapC Uniprot ID V6AG16
Locus tag NQ602_RS15580 Protein ID WP_003088107.1
Coordinates 3259037..3259615 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NQ602_RS15585 Protein ID WP_003088112.1
Coordinates 3259704..3260258 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQ602_RS15565 (NQ602_15565) 3254313..3255590 + 1278 WP_003088104.1 TolC family protein -
NQ602_RS15570 (NQ602_15570) 3255580..3257751 + 2172 WP_003088105.1 type I secretion system permease/ATPase -
NQ602_RS15575 (NQ602_15575) 3257741..3258928 + 1188 WP_003088106.1 HlyD family efflux transporter periplasmic adaptor subunit -
NQ602_RS15580 (NQ602_15580) 3259037..3259615 - 579 WP_003088107.1 HD domain-containing protein Toxin
NQ602_RS15585 (NQ602_15585) 3259704..3260258 - 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
NQ602_RS15590 (NQ602_15590) 3260416..3262611 - 2196 WP_003088114.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
NQ602_RS15595 (NQ602_15595) 3262616..3263077 - 462 WP_003088117.1 (2Fe-2S)-binding protein -
NQ602_RS15600 (NQ602_15600) 3263408..3263731 + 324 WP_003102734.1 multidrug efflux SMR transporter -
NQ602_RS15605 (NQ602_15605) 3263744..3264142 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
NQ602_RS15610 (NQ602_15610) 3264139..3264690 - 552 WP_023098678.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-187)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21885.74 Da        Isoelectric Point: 5.3655

>T253269 WP_003088107.1 NZ_CP102174:c3259615-3259037 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDAKTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT253269 WP_003088112.1 NZ_CP102174:c3260258-3259704 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AG16

Antitoxin

Source ID Structure

References