253267

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 183635..184140 Replicon chromosome
Accession NZ_CP102174
Organism Pseudomonas aeruginosa strain PA5083

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag NQ602_RS00805 Protein ID WP_003083773.1
Coordinates 183635..183916 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag NQ602_RS00810 Protein ID WP_003083775.1
Coordinates 183913..184140 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQ602_RS00780 (NQ602_00780) 178886..180235 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
NQ602_RS00785 (NQ602_00785) 180284..180970 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
NQ602_RS00790 (NQ602_00790) 181071..181805 + 735 WP_003083764.1 GntR family transcriptional regulator -
NQ602_RS00795 (NQ602_00795) 181985..182395 + 411 WP_003110659.1 aegerolysin family protein -
NQ602_RS00800 (NQ602_00800) 182427..183335 - 909 WP_003083769.1 LysR family transcriptional regulator -
NQ602_RS00805 (NQ602_00805) 183635..183916 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
NQ602_RS00810 (NQ602_00810) 183913..184140 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
NQ602_RS00815 (NQ602_00815) 184316..184936 - 621 WP_003101226.1 hypothetical protein -
NQ602_RS00820 (NQ602_00820) 185037..185537 + 501 WP_003083778.1 LEA type 2 family protein -
NQ602_RS00825 (NQ602_00825) 185610..185951 + 342 WP_014603467.1 zinc ribbon domain-containing protein YjdM -
NQ602_RS00830 (NQ602_00830) 186033..187460 - 1428 WP_003083784.1 GABA permease -
NQ602_RS00835 (NQ602_00835) 187629..189122 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T253267 WP_003083773.1 NZ_CP102174:c183916-183635 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT253267 WP_003083775.1 NZ_CP102174:c184140-183913 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References