Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 858826..859318 Replicon chromosome
Accession NZ_CP102154
Organism Streptococcus suis strain SS15055_N2_C15

Toxin (Protein)


Gene name relE Uniprot ID D5AHJ6
Locus tag NQZ87_RS04200 Protein ID WP_011922404.1
Coordinates 858826..859083 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AHJ7
Locus tag NQZ87_RS04205 Protein ID WP_012775104.1
Coordinates 859067..859318 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ87_RS04180 (NQZ87_04180) 854460..855530 + 1071 WP_012775101.1 tyrosine recombinase XerS -
NQZ87_RS04185 (NQZ87_04185) 855600..857108 - 1509 WP_011922400.1 phosphomannomutase/phosphoglucomutase -
NQZ87_RS04190 (NQZ87_04190) 857184..858125 - 942 WP_012775102.1 sensor histidine kinase -
NQZ87_RS04195 (NQZ87_04195) 858122..858787 - 666 WP_012775103.1 response regulator transcription factor -
NQZ87_RS04200 (NQZ87_04200) 858826..859083 - 258 WP_011922404.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NQZ87_RS04205 (NQZ87_04205) 859067..859318 - 252 WP_012775104.1 DUF6290 family protein Antitoxin
NQZ87_RS04210 (NQZ87_04210) 859410..861380 - 1971 WP_012775105.1 FtsX-like permease family protein -
NQZ87_RS04215 (NQZ87_04215) 861381..862133 - 753 WP_011922409.1 ABC transporter ATP-binding protein -
NQZ87_RS04220 (NQZ87_04220) 862269..863003 - 735 WP_011922410.1 ABC transporter permease -
NQZ87_RS04225 (NQZ87_04225) 863005..863751 - 747 WP_011922411.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-75)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9981.62 Da        Isoelectric Point: 10.8924

>T253263 WP_011922404.1 NZ_CP102154:c859083-858826 [Streptococcus suis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9325.59 Da        Isoelectric Point: 3.7666

>AT253263 WP_012775104.1 NZ_CP102154:c859318-859067 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALSEYEADLAKGIEPISWEEMLEELGLTDE
DLL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8U747

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9GU89

References