Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 597095..597581 Replicon chromosome
Accession NZ_CP102154
Organism Streptococcus suis strain SS15055_N2_C15

Toxin (Protein)


Gene name relE Uniprot ID D5AGV2
Locus tag NQZ87_RS02975 Protein ID WP_011922754.1
Coordinates 597312..597581 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag NQZ87_RS02970 Protein ID WP_002938604.1
Coordinates 597095..597322 (+) Length 76 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ87_RS02945 (NQZ87_02945) 592138..592587 - 450 WP_009909619.1 MarR family transcriptional regulator -
NQZ87_RS02950 (NQZ87_02950) 592881..593728 + 848 WP_087892711.1 IS630 family transposase -
NQZ87_RS02955 (NQZ87_02955) 593787..594284 + 498 WP_011922751.1 DUF5590 domain-containing protein -
NQZ87_RS02960 (NQZ87_02960) 594281..595462 + 1182 WP_011922154.1 pyridoxal phosphate-dependent aminotransferase -
NQZ87_RS02965 (NQZ87_02965) 595477..596823 + 1347 WP_011922752.1 asparagine--tRNA ligase -
NQZ87_RS02970 (NQZ87_02970) 597095..597322 + 228 WP_002938604.1 DUF6290 family protein Antitoxin
NQZ87_RS02975 (NQZ87_02975) 597312..597581 + 270 WP_011922754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NQZ87_RS02980 (NQZ87_02980) 597987..599306 + 1320 WP_012775027.1 MATE family efflux transporter -
NQZ87_RS02985 (NQZ87_02985) 599357..599734 + 378 WP_002937263.1 RidA family protein -
NQZ87_RS02990 (NQZ87_02990) 599756..600643 + 888 WP_011922160.1 RNase adapter RapZ -
NQZ87_RS02995 (NQZ87_02995) 600640..601614 + 975 WP_002937257.1 YvcK family protein -
NQZ87_RS03000 (NQZ87_03000) 601611..602528 + 918 WP_002937252.1 DNA-binding protein WhiA -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 90 a.a.        Molecular weight: 10437.49 Da        Isoelectric Point: 10.3916

>T253262 WP_011922754.1 NZ_CP102154:597312-597581 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp


Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT253262 WP_002938604.1 NZ_CP102154:597095-597322 [Streptococcus suis]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A126UKS2


Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References