253259

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1030542..1031043 Replicon chromosome
Accession NZ_CP102152
Organism Streptococcus suis strain DNS11

Toxin (Protein)


Gene name relE Uniprot ID A0A0M9FF45
Locus tag NQZ88_RS05235 Protein ID WP_024405694.1
Coordinates 1030542..1030808 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AHJ7
Locus tag NQZ88_RS05240 Protein ID WP_012775104.1
Coordinates 1030792..1031043 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ88_RS05210 (NQZ88_05210) 1025772..1026008 + 237 WP_226319150.1 hypothetical protein -
NQZ88_RS05215 (NQZ88_05215) 1026174..1027244 + 1071 WP_024405698.1 tyrosine recombinase XerS -
NQZ88_RS05220 (NQZ88_05220) 1027314..1028822 - 1509 WP_024405697.1 phosphoglucomutase -
NQZ88_RS05225 (NQZ88_05225) 1028897..1029838 - 942 WP_024405696.1 sensor histidine kinase -
NQZ88_RS05230 (NQZ88_05230) 1029835..1030500 - 666 WP_024405695.1 response regulator transcription factor -
NQZ88_RS05235 (NQZ88_05235) 1030542..1030808 - 267 WP_024405694.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NQZ88_RS05240 (NQZ88_05240) 1030792..1031043 - 252 WP_012775104.1 DUF6290 family protein Antitoxin
NQZ88_RS05245 (NQZ88_05245) 1031135..1033105 - 1971 WP_024405693.1 FtsX-like permease family protein -
NQZ88_RS05250 (NQZ88_05250) 1033106..1033858 - 753 WP_011922409.1 ABC transporter ATP-binding protein -
NQZ88_RS05255 (NQZ88_05255) 1033879..1034256 - 378 WP_011922413.1 NisI/SpaI family lantibiotic immunity lipoprotein -
NQZ88_RS05260 (NQZ88_05260) 1034269..1034409 - 141 WP_012775106.1 hypothetical protein -
NQZ88_RS05265 (NQZ88_05265) 1034549..1035715 - 1167 WP_011922414.1 carbamoyl phosphate synthase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 985803..1188254 202451


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-87)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10392.08 Da        Isoelectric Point: 10.6122

>T253259 WP_024405694.1 NZ_CP102152:c1030808-1030542 [Streptococcus suis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEDDKLIVTALEV
GHRKEIYK

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9325.59 Da        Isoelectric Point: 3.7666

>AT253259 WP_012775104.1 NZ_CP102152:c1031043-1030792 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALSEYEADLAKGIEPISWEEMLEELGLTDE
DLL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M9FF45

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9GU89

References