253258

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 750565..751051 Replicon chromosome
Accession NZ_CP102152
Organism Streptococcus suis strain DNS11

Toxin (Protein)


Gene name relE Uniprot ID D5AGV2
Locus tag NQZ88_RS03920 Protein ID WP_011922754.1
Coordinates 750782..751051 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag NQZ88_RS03915 Protein ID WP_002938604.1
Coordinates 750565..750792 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ88_RS03890 (NQZ88_03890) 745897..746442 - 546 WP_002941732.1 NADPH-dependent FMN reductase -
NQZ88_RS03895 (NQZ88_03895) 746505..746954 - 450 WP_024383028.1 MarR family transcriptional regulator -
NQZ88_RS03900 (NQZ88_03900) 747257..747754 + 498 WP_024405519.1 DUF5590 domain-containing protein -
NQZ88_RS03905 (NQZ88_03905) 747751..748932 + 1182 WP_024383693.1 pyridoxal phosphate-dependent aminotransferase -
NQZ88_RS03910 (NQZ88_03910) 748947..750293 + 1347 WP_074389302.1 asparagine--tRNA ligase -
NQZ88_RS03915 (NQZ88_03915) 750565..750792 + 228 WP_002938604.1 DUF6290 family protein Antitoxin
NQZ88_RS03920 (NQZ88_03920) 750782..751051 + 270 WP_011922754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NQZ88_RS03925 (NQZ88_03925) 751457..752781 + 1325 Protein_738 MATE family efflux transporter -
NQZ88_RS03930 (NQZ88_03930) 752965..753342 + 378 WP_002937263.1 RidA family protein -
NQZ88_RS03935 (NQZ88_03935) 753364..754251 + 888 WP_002937261.1 RNase adapter RapZ -
NQZ88_RS03940 (NQZ88_03940) 754248..755222 + 975 WP_024383695.1 YvcK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10437.49 Da        Isoelectric Point: 10.3916

>T253258 WP_011922754.1 NZ_CP102152:750782-751051 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT253258 WP_002938604.1 NZ_CP102152:750565-750792 [Streptococcus suis]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126UKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References