253257

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 605456..605939 Replicon chromosome
Accession NZ_CP102152
Organism Streptococcus suis strain DNS11

Toxin (Protein)


Gene name relE Uniprot ID D5AIX4
Locus tag NQZ88_RS03215 Protein ID WP_012027435.1
Coordinates 605679..605939 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag NQZ88_RS03210 Protein ID WP_012775256.1
Coordinates 605456..605677 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ88_RS03185 (NQZ88_03185) 601124..601774 - 651 WP_023370907.1 HAD family hydrolase -
NQZ88_RS03190 (NQZ88_03190) 601882..603009 + 1128 WP_257116234.1 glycerate kinase -
NQZ88_RS03195 (NQZ88_03195) 603000..603230 + 231 WP_023370903.1 hypothetical protein -
NQZ88_RS03200 (NQZ88_03200) 603237..603689 - 453 WP_024383805.1 DUF1694 domain-containing protein -
NQZ88_RS03205 (NQZ88_03205) 603839..605146 + 1308 WP_002935704.1 phosphopyruvate hydratase -
NQZ88_RS03210 (NQZ88_03210) 605456..605677 + 222 WP_012775256.1 DUF6290 family protein Antitoxin
NQZ88_RS03215 (NQZ88_03215) 605679..605939 + 261 WP_012027435.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NQZ88_RS03220 (NQZ88_03220) 606106..606747 + 642 WP_023370899.1 HAD family hydrolase -
NQZ88_RS03225 (NQZ88_03225) 606780..606965 - 186 WP_002935693.1 hypothetical protein -
NQZ88_RS03230 (NQZ88_03230) 607029..608033 - 1005 WP_023370897.1 lactonase family protein -
NQZ88_RS03235 (NQZ88_03235) 608169..609335 + 1167 WP_012775254.1 AI-2E family transporter -
NQZ88_RS03240 (NQZ88_03240) 609325..610554 + 1230 WP_023370895.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 599486..600688 1202


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10273.79 Da        Isoelectric Point: 9.3944

>T253257 WP_012027435.1 NZ_CP102152:605679-605939 [Streptococcus suis]
MYHLEYSKKAQKQIMKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT253257 WP_012775256.1 NZ_CP102152:605456-605677 [Streptococcus suis]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1T1M7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References