Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-couple_hipB
Location 1292140..1293392 Replicon chromosome
Accession NZ_CP102149
Organism Streptococcus suis strain DNC13

Toxin (Protein)


Gene name sezT Uniprot ID -
Locus tag NQZ89_RS06685 Protein ID WP_257103945.1
Coordinates 1292616..1293392 (+) Length 259 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag NQZ89_RS06680 Protein ID WP_257103944.1
Coordinates 1292140..1292616 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ89_RS06660 (NQZ89_06660) 1287862..1289013 - 1152 WP_105111097.1 glycerophosphodiester phosphodiesterase family protein -
NQZ89_RS06665 (NQZ89_06665) 1289117..1289881 - 765 WP_257103943.1 alpha/beta hydrolase -
NQZ89_RS06670 (NQZ89_06670) 1290100..1290690 + 591 WP_105111096.1 CHAP domain-containing protein -
NQZ89_RS06675 (NQZ89_06675) 1290828..1292024 + 1197 WP_257105021.1 iron-containing alcohol dehydrogenase -
NQZ89_RS06680 (NQZ89_06680) 1292140..1292616 + 477 WP_257103944.1 type II toxin-antitoxin system antitoxin PezA Antitoxin
NQZ89_RS06685 (NQZ89_06685) 1292616..1293392 + 777 WP_257103945.1 type II toxin-antitoxin system toxin PezT Toxin
NQZ89_RS06690 (NQZ89_06690) 1293673..1294441 + 769 Protein_1269 DeoR/GlpR family DNA-binding transcription regulator -
NQZ89_RS06695 (NQZ89_06695) 1294644..1295066 + 423 WP_257103946.1 galactose-6-phosphate isomerase subunit LacA -
NQZ89_RS06700 (NQZ89_06700) 1295093..1295608 + 516 WP_172145136.1 galactose-6-phosphate isomerase subunit LacB -
NQZ89_RS06705 (NQZ89_06705) 1295618..1296550 + 933 WP_257103947.1 tagatose-6-phosphate kinase -
NQZ89_RS06710 (NQZ89_06710) 1296552..1297529 + 978 WP_257103948.1 tagatose-bisphosphate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(28-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 259 a.a.        Molecular weight: 29439.28 Da        Isoelectric Point: 5.2731

>T253252 WP_257103945.1 NZ_CP102149:1292616-1293392 [Streptococcus suis]
MRLEEFSEADFQKALQRTIRALTRGKTIPDRPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSCRSQHPNYLALQE
EYGKDSVDYTKGFAGKMVEQLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLASKGYQVSLAIIGTKPELSYLSTLIRYEE
LYAIDPNQARATPKEHHDGIVENLVDNLRELESEKLFERIQIYQRDRTCIYDSESDEGFVAEVLQECLFGKWSKVEEEMM
KFGQERLREMSKSNGNDV

Download         Length: 777 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18285.73 Da        Isoelectric Point: 4.3452

>AT253252 WP_257103944.1 NZ_CP102149:1292140-1292616 [Streptococcus suis]
MIGENIKSLRQTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYQLTLKIE
VIKERGAAILSQLYRYQDSQEIAFDDEANPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLEMVHHRVVA

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References