Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 52603..53104 Replicon chromosome
Accession NZ_CP102149
Organism Streptococcus suis strain DNC13

Toxin (Protein)


Gene name relE Uniprot ID A0A0M9FF45
Locus tag NQZ89_RS00235 Protein ID WP_024405694.1
Coordinates 52838..53104 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3R8T0W2
Locus tag NQZ89_RS00230 Protein ID WP_044675807.1
Coordinates 52603..52854 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ89_RS00200 (NQZ89_00200) 48255..48392 + 138 WP_162840723.1 hypothetical protein -
NQZ89_RS00205 (NQZ89_00205) 48405..49139 + 735 WP_257104501.1 conjugal transfer protein TraX -
NQZ89_RS00210 (NQZ89_00210) 49238..49378 + 141 WP_105108623.1 hypothetical protein -
NQZ89_RS00215 (NQZ89_00215) 49391..49780 + 390 WP_257104502.1 NisI/SpaI family lantibiotic immunity lipoprotein -
NQZ89_RS00220 (NQZ89_00220) 49789..50541 + 753 WP_257104503.1 ABC transporter ATP-binding protein -
NQZ89_RS00225 (NQZ89_00225) 50542..52512 + 1971 WP_257104504.1 FtsX-like permease family protein -
NQZ89_RS00230 (NQZ89_00230) 52603..52854 + 252 WP_044675807.1 DUF6290 family protein Antitoxin
NQZ89_RS00235 (NQZ89_00235) 52838..53104 + 267 WP_024405694.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NQZ89_RS00240 (NQZ89_00240) 53146..53811 + 666 WP_257104505.1 response regulator transcription factor -
NQZ89_RS00245 (NQZ89_00245) 53808..54749 + 942 WP_257104506.1 sensor histidine kinase -
NQZ89_RS00250 (NQZ89_00250) 54825..56333 + 1509 WP_257104507.1 phosphomannomutase/phosphoglucomutase -
NQZ89_RS00255 (NQZ89_00255) 56501..57793 + 1293 WP_257104508.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-87)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10392.08 Da        Isoelectric Point: 10.6122

>T253251 WP_024405694.1 NZ_CP102149:52838-53104 [Streptococcus suis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEDDKLIVTALEV
GHRKEIYK

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9309.59 Da        Isoelectric Point: 3.7666

>AT253251 WP_044675807.1 NZ_CP102149:52603-52854 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALAEYEADLAKGIEPISWEEMLEELGLTDE
DLL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M9FF45

Antitoxin

Source ID Structure
AlphaFold DB A0A3R8T0W2

References