253247

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1011091..1011586 Replicon chromosome
Accession NZ_CP102148
Organism Streptococcus suis strain DNC15

Toxin (Protein)


Gene name relE Uniprot ID A0A0Z8F7Q7
Locus tag NQZ90_RS04925 Protein ID WP_024401228.1
Coordinates 1011320..1011586 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A123SEG2
Locus tag NQZ90_RS04920 Protein ID WP_015646833.1
Coordinates 1011091..1011330 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ90_RS04895 (NQZ90_04895) 1006417..1007583 + 1167 WP_044752108.1 carbamoyl phosphate synthase large subunit -
NQZ90_RS04900 (NQZ90_04900) 1007723..1007863 + 141 WP_032500796.1 hypothetical protein -
NQZ90_RS04905 (NQZ90_04905) 1007876..1008259 + 384 WP_257110402.1 NisI/SpaI family lantibiotic immunity lipoprotein -
NQZ90_RS04910 (NQZ90_04910) 1008276..1009028 + 753 WP_257110403.1 ABC transporter ATP-binding protein -
NQZ90_RS04915 (NQZ90_04915) 1009029..1010999 + 1971 WP_257110404.1 ABC transporter permease -
NQZ90_RS04920 (NQZ90_04920) 1011091..1011330 + 240 WP_015646833.1 DUF6290 family protein Antitoxin
NQZ90_RS04925 (NQZ90_04925) 1011320..1011586 + 267 WP_024401228.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NQZ90_RS04930 (NQZ90_04930) 1011625..1012293 + 669 WP_257110405.1 response regulator transcription factor -
NQZ90_RS04935 (NQZ90_04935) 1012290..1013231 + 942 WP_257110406.1 sensor histidine kinase -
NQZ90_RS04940 (NQZ90_04940) 1013308..1014816 + 1509 WP_257110407.1 phosphomannomutase/phosphoglucomutase -
NQZ90_RS04945 (NQZ90_04945) 1014879..1015949 - 1071 WP_257110408.1 tyrosine recombinase XerS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10259.98 Da        Isoelectric Point: 10.4518

>T253247 WP_024401228.1 NZ_CP102148:1011320-1011586 [Streptococcus suis]
MSYKVILSAKAQKQIRKMDKTAASLILRYLYKHIDGCDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEDDKLIVTALEV
GHRKEIYK

Download         Length: 267 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8879.09 Da        Isoelectric Point: 3.7832

>AT253247 WP_015646833.1 NZ_CP102148:1011091-1011330 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIAWAEYQEDLANGIEPITLEQMAEELGIEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8F7Q7

Antitoxin

Source ID Structure
AlphaFold DB A0A123SEG2

References