Detailed information of TA system TA253240

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 359149..360581
• Replicon: chromosome
• Accession: NZ_CP102145
• Organism: Streptococcus suis strain DNS20

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: -
• Locus tag: NQZ91_RS01745
• Protein ID: WP_257104486.1
• Coordinates: 359736..360581 (+)
• Length: 282 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: -
• Locus tag: NQZ91_RS01740
• Protein ID: WP_257104487.1
• Coordinates: 359149..359739 (+)
• Length: 197 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NQZ91_RS01740 (NQZ91_01740)	359149..359739	+	591	WP_257104487.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
NQZ91_RS01745 (NQZ91_01745)	359736..360581	+	846	WP_257104486.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
NQZ91_RS01750 (NQZ91_01750)	360667..360951	-	285	Protein_344	CHAP domain-containing protein	-
NQZ91_RS01755 (NQZ91_01755)	361224..362387	+	1164	WP_257117355.1	IS30 family transposase	-
NQZ91_RS01760 (NQZ91_01760)	362634..363626	-	993	WP_257117725.1	Abi family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	361224..362387	1163

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-258)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (6-50)

Sequences

Toxin

Protein

• Length: 282 a.a.
• Molecular weight: 32394.95 Da
• Isoelectric Point: 4.8302

>T253240 WP_257104486.1 NZ_CP102145:359736-360581 [Streptococcus suis]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSSYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQITLSEE
TVKQQLEEVLADSDEGISFVIQSITAIKESDDYGGYRATILCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEDNFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLRNACQRTFSYRETELDFVKIIELLERFKSDP
IQNKQWQNYSKKYSYTKGISLADVLDEMISLITIIISTDSD

Nucleotide

• Length: 846 bp

Antitoxin

Protein

• Length: 197 a.a.
• Molecular weight: 23046.57 Da
• Isoelectric Point: 7.8056

>AT253240 WP_257104487.1 NZ_CP102145:359149-359739 [Streptococcus suis]
MSKKEILLDFIEKNNGIVTNKDCKALGIPTIYLTRLEKEGIIFRVEKGIFLTQNGDYDEYYFFQYRFPKAIFSYISALYL
QQFTDEIPQYFDVTVPRGYRFNTPPANLNIHFVSKEYSELGMTTVPTPMGNNVRVYDFERVICDFVIHREKIDSELFVKT
LQSYGNYPKKNLAKLYEYATKMNTLEKVKQTLEVLV

Nucleotide

• Length: 591 bp