Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 326834..327335 Replicon chromosome
Accession NZ_CP102145
Organism Streptococcus suis strain DNS20

Toxin (Protein)


Gene name relE Uniprot ID A0A0Z8GZU5
Locus tag NQZ91_RS01605 Protein ID WP_024397888.1
Coordinates 326834..327100 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8G1U4
Locus tag NQZ91_RS01610 Protein ID WP_024397889.1
Coordinates 327084..327335 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ91_RS01585 (NQZ91_01585) 322166..323458 - 1293 WP_257117704.1 hypothetical protein -
NQZ91_RS01590 (NQZ91_01590) 323626..325131 - 1506 WP_257117705.1 phosphomannomutase/phosphoglucomutase -
NQZ91_RS01595 (NQZ91_01595) 325192..326130 - 939 WP_257117706.1 sensor histidine kinase -
NQZ91_RS01600 (NQZ91_01600) 326127..326795 - 669 WP_257117707.1 response regulator transcription factor -
NQZ91_RS01605 (NQZ91_01605) 326834..327100 - 267 WP_024397888.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NQZ91_RS01610 (NQZ91_01610) 327084..327335 - 252 WP_024397889.1 DUF6290 family protein Antitoxin
NQZ91_RS01615 (NQZ91_01615) 327428..329398 - 1971 WP_257117708.1 FtsX-like permease family protein -
NQZ91_RS01620 (NQZ91_01620) 329399..330151 - 753 WP_257117709.1 ABC transporter ATP-binding protein -
NQZ91_RS01625 (NQZ91_01625) 330160..330549 - 390 WP_105160935.1 NisI/SpaI family lantibiotic immunity lipoprotein -
NQZ91_RS01630 (NQZ91_01630) 330562..330702 - 141 WP_105108623.1 hypothetical protein -
NQZ91_RS01635 (NQZ91_01635) 330801..331535 - 735 WP_257117710.1 conjugal transfer protein TraX -
NQZ91_RS01640 (NQZ91_01640) 331548..331685 - 138 WP_172015819.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-87)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10378.05 Da        Isoelectric Point: 10.6122

>T253239 WP_024397888.1 NZ_CP102145:c327100-326834 [Streptococcus suis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEDDKLIVTALEV
GHRKEVYK

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9367.59 Da        Isoelectric Point: 3.7031

>AT253239 WP_024397889.1 NZ_CP102145:c327335-327084 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIAWAEYQADLANGIEPISWEEMLEELGLTDE
DLL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8GZU5

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8G1U4

References