253236

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1508444..1508927 Replicon chromosome
Accession NZ_CP102143
Organism Streptococcus suis strain DNR43

Toxin (Protein)


Gene name relE Uniprot ID A0A0Z8BIZ7
Locus tag NQZ92_RS07670 Protein ID WP_009910443.1
Coordinates 1508444..1508704 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag NQZ92_RS07675 Protein ID WP_012775256.1
Coordinates 1508706..1508927 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ92_RS07645 (NQZ92_07645) 1503829..1505058 - 1230 WP_009910437.1 tetratricopeptide repeat protein -
NQZ92_RS07650 (NQZ92_07650) 1505048..1506214 - 1167 WP_002935690.1 AI-2E family transporter -
NQZ92_RS07655 (NQZ92_07655) 1506350..1507354 + 1005 WP_009910438.1 lactonase family protein -
NQZ92_RS07660 (NQZ92_07660) 1507418..1507603 + 186 WP_002935693.1 hypothetical protein -
NQZ92_RS07665 (NQZ92_07665) 1507636..1508277 - 642 WP_002935700.1 HAD family hydrolase -
NQZ92_RS07670 (NQZ92_07670) 1508444..1508704 - 261 WP_009910443.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NQZ92_RS07675 (NQZ92_07675) 1508706..1508927 - 222 WP_012775256.1 DUF6290 family protein Antitoxin
NQZ92_RS07680 (NQZ92_07680) 1510034..1510243 - 210 WP_009910447.1 hypothetical protein -
NQZ92_RS07685 (NQZ92_07685) 1510355..1510807 - 453 WP_009910448.1 type II toxin-antitoxin system HicB family antitoxin -
NQZ92_RS07690 (NQZ92_07690) 1510847..1511029 - 183 WP_009910449.1 type II toxin-antitoxin system HicA family toxin -
NQZ92_RS07695 (NQZ92_07695) 1511213..1511599 - 387 WP_009910450.1 hypothetical protein -
NQZ92_RS07700 (NQZ92_07700) 1511739..1512239 - 501 WP_024409209.1 hypothetical protein -
NQZ92_RS07705 (NQZ92_07705) 1512309..1512749 - 441 WP_024409208.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1507418..1518533 11115


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10270.78 Da        Isoelectric Point: 9.6925

>T253236 WP_009910443.1 NZ_CP102143:c1508704-1508444 [Streptococcus suis]
MYHLEYSKKAQKQIKKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT253236 WP_012775256.1 NZ_CP102143:c1508927-1508706 [Streptococcus suis]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8BIZ7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References