Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | sezT-pezT/zeta-couple_hipB |
| Location | 1132492..1133762 | Replicon | chromosome |
| Accession | NZ_CP102143 | ||
| Organism | Streptococcus suis strain DNR43 | ||
Toxin (Protein)
| Gene name | sezT | Uniprot ID | A0A0Z8INM2 |
| Locus tag | NQZ92_RS05845 | Protein ID | WP_024409332.1 |
| Coordinates | 1132492..1133286 (-) | Length | 265 a.a. |
Antitoxin (Protein)
| Gene name | pezT | Uniprot ID | - |
| Locus tag | NQZ92_RS05850 | Protein ID | WP_024409333.1 |
| Coordinates | 1133286..1133762 (-) | Length | 159 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NQZ92_RS05825 (NQZ92_05825) | 1127520..1129445 | - | 1926 | WP_024409328.1 | ATP-dependent helicase | - |
| NQZ92_RS05830 (NQZ92_05830) | 1129442..1131271 | - | 1830 | WP_024409329.1 | AAA family ATPase | - |
| NQZ92_RS05835 (NQZ92_05835) | 1131273..1132217 | - | 945 | WP_226960621.1 | IS30 family transposase | - |
| NQZ92_RS05840 (NQZ92_05840) | 1132302..1132511 | - | 210 | WP_024409331.1 | AAA family ATPase | - |
| NQZ92_RS05845 (NQZ92_05845) | 1132492..1133286 | - | 795 | WP_024409332.1 | type II toxin-antitoxin system toxin PezT | Toxin |
| NQZ92_RS05850 (NQZ92_05850) | 1133286..1133762 | - | 477 | WP_024409333.1 | type II toxin-antitoxin system antitoxin PezA | Antitoxin |
| NQZ92_RS05855 (NQZ92_05855) | 1133832..1134116 | - | 285 | WP_024409334.1 | hypothetical protein | - |
| NQZ92_RS05860 (NQZ92_05860) | 1134160..1134555 | - | 396 | WP_017285409.1 | DUF5945 family protein | - |
| NQZ92_RS05865 (NQZ92_05865) | 1134559..1134786 | - | 228 | WP_024409335.1 | DUF5965 family protein | - |
| NQZ92_RS05870 (NQZ92_05870) | 1134840..1135928 | - | 1089 | WP_024409336.1 | toprim domain-containing protein | - |
| NQZ92_RS05875 (NQZ92_05875) | 1135968..1136606 | - | 639 | WP_024409337.1 | hypothetical protein | - |
| NQZ92_RS05880 (NQZ92_05880) | 1136717..1137007 | - | 291 | WP_024409338.1 | DUF5966 family protein | - |
| NQZ92_RS05885 (NQZ92_05885) | 1137022..1137321 | - | 300 | WP_024382151.1 | DUF5962 family protein | - |
| NQZ92_RS05890 (NQZ92_05890) | 1137391..1138338 | - | 948 | WP_226960637.1 | helicase SNF2 | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | tet(O) | - | 1111526..1172543 | 61017 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 265 a.a. Molecular weight: 30360.57 Da Isoelectric Point: 6.6151
>T253235 WP_024409332.1 NZ_CP102143:c1133286-1132492 [Streptococcus suis]
MRLEEFSKDDFDLALKRTIRSLTRGKTTSVTPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSLHPNYLTLQE
EYGKDSVDYTKGFAGKMVEQLVDELSKQGYHLLIEGTLRTTEVPRKTARLLKARGYQVSLALIATKPELSYLSTLIRYEE
VYVVNPNQARATPKEHHDGIVNHLVDNLRELENDHLFDYIQIYQRDRSCVYDSETDDGSAAEVLQECLFGKWSKVEEEMM
KMGQELLMEFLEMKKGRIYENKKN
MRLEEFSKDDFDLALKRTIRSLTRGKTTSVTPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSLHPNYLTLQE
EYGKDSVDYTKGFAGKMVEQLVDELSKQGYHLLIEGTLRTTEVPRKTARLLKARGYQVSLALIATKPELSYLSTLIRYEE
VYVVNPNQARATPKEHHDGIVNHLVDNLRELENDHLFDYIQIYQRDRSCVYDSETDDGSAAEVLQECLFGKWSKVEEEMM
KMGQELLMEFLEMKKGRIYENKKN
Download Length: 795 bp
Antitoxin
Download Length: 159 a.a. Molecular weight: 18119.46 Da Isoelectric Point: 4.3193
>AT253235 WP_024409333.1 NZ_CP102143:c1133762-1133286 [Streptococcus suis]
MIGDNIKSLRKTHDLTQPEFAKIVGISRNSLSRYENGTSSLSTELIDRICQKFNVSYVDIVGEEKMLTPVEDYQLTLKIE
VIKERGAAILSELYRYQDSQGITFDDETSPWILMSDDLSDLINTKIYLVNTFDEVERYNGYLDGIERMLELANHQVVA
MIGDNIKSLRKTHDLTQPEFAKIVGISRNSLSRYENGTSSLSTELIDRICQKFNVSYVDIVGEEKMLTPVEDYQLTLKIE
VIKERGAAILSELYRYQDSQGITFDDETSPWILMSDDLSDLINTKIYLVNTFDEVERYNGYLDGIERMLELANHQVVA
Download Length: 477 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|