253234

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1050418..1050904 Replicon chromosome
Accession NZ_CP102143
Organism Streptococcus suis strain DNR43

Toxin (Protein)


Gene name relE Uniprot ID A0A0K2E5U8
Locus tag NQZ92_RS05455 Protein ID WP_002935012.1
Coordinates 1050418..1050675 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0K2E5B0
Locus tag NQZ92_RS05460 Protein ID WP_002935014.1
Coordinates 1050665..1050904 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ92_RS05435 (NQZ92_05435) 1046052..1047122 + 1071 WP_002935006.1 tyrosine recombinase XerS -
NQZ92_RS05440 (NQZ92_05440) 1047192..1048700 - 1509 WP_013730362.1 phosphoglucomutase -
NQZ92_RS05445 (NQZ92_05445) 1048776..1049717 - 942 WP_002935009.1 sensor histidine kinase -
NQZ92_RS05450 (NQZ92_05450) 1049714..1050379 - 666 WP_009909826.1 response regulator transcription factor -
NQZ92_RS05455 (NQZ92_05455) 1050418..1050675 - 258 WP_002935012.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NQZ92_RS05460 (NQZ92_05460) 1050665..1050904 - 240 WP_002935014.1 DUF6290 family protein Antitoxin
NQZ92_RS05465 (NQZ92_05465) 1050996..1052966 - 1971 WP_013730363.1 FtsX-like permease family protein -
NQZ92_RS05470 (NQZ92_05470) 1052967..1053719 - 753 WP_002935019.1 ABC transporter ATP-binding protein -
NQZ92_RS05475 (NQZ92_05475) 1053736..1054119 - 384 WP_002935021.1 NisI/SpaI family lantibiotic immunity lipoprotein -
NQZ92_RS05480 (NQZ92_05480) 1054132..1054272 - 141 WP_002935023.1 hypothetical protein -
NQZ92_RS05485 (NQZ92_05485) 1054371..1055105 - 735 WP_002935025.1 TraX family protein -
NQZ92_RS05490 (NQZ92_05490) 1055118..1055255 - 138 WP_002935027.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-75)

Antitoxin

Protein of unknown function DUF6290

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9849.52 Da        Isoelectric Point: 10.7134

>T253234 WP_002935012.1 NZ_CP102143:c1050675-1050418 [Streptococcus suis]
MSYKVILSAKAQKQIRKMDKTAASLILRYLYKHIDGCDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8924.19 Da        Isoelectric Point: 3.9191

>AT253234 WP_002935014.1 NZ_CP102143:c1050904-1050665 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADVAWAEYQADLANRIEPMTLEQMAEELGIEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2E5U8

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E5B0

References