Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 2098243..2099675 Replicon chromosome
Accession NZ_CP102141
Organism Streptococcus suis strain DNR48

Toxin (Protein)


Gene name abiEi Uniprot ID -
Locus tag NQZ93_RS10460 Protein ID WP_024388330.1
Coordinates 2098830..2099675 (+) Length 282 a.a.

Antitoxin (Protein)


Gene name abiEii Uniprot ID A0A6G6AVK6
Locus tag NQZ93_RS10455 Protein ID WP_074390956.1
Coordinates 2098243..2098833 (+) Length 197 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ93_RS10455 (NQZ93_10455) 2098243..2098833 + 591 WP_074390956.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
NQZ93_RS10460 (NQZ93_10460) 2098830..2099675 + 846 WP_024388330.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
NQZ93_RS10465 (NQZ93_10465) 2099737..2102538 - 2802 WP_024388329.1 phage tail tip lysozyme -
NQZ93_RS10470 (NQZ93_10470) 2102540..2103421 - 882 Protein_2025 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-258)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(6-50)


Sequences

Toxin        


Download         Length: 282 a.a.        Molecular weight: 32474.19 Da        Isoelectric Point: 5.4360

>T253231 WP_024388330.1 NZ_CP102141:2098830-2099675 [Streptococcus suis]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSTYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQITLSED
TVKQQLKEILADSEEGISFVIQSITAIKESDDYGGYRATILCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEDNFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLRNACQRTFSYRETELDFVKIIELLERFKSDP
IQNKQWQNYSKKYSYTKGISLADVLDEMIRLITVLVSINSD

Download         Length: 846 bp

Antitoxin


Download         Length: 197 a.a.        Molecular weight: 23279.87 Da        Isoelectric Point: 7.8482

>AT253231 WP_074390956.1 NZ_CP102141:2098243-2098833 [Streptococcus suis]
MSKKEILLEFIENHNGIITYKDCKALKIPTIYLTRLEKEGILYRVEKGIFLTQNGDYDEYYFFQYRYPKAIFSYISALYL
QQFTDEIPQYFDVTIPRGYRFNTPPANLNIHSVSKEYSELGITLVKTPMGNEVRVYDLERIICDFVIHREKIDTELFVKT
LQHYGNYSKKNLTKLYEYATKMNTLDKVKQTLEVLV

Download         Length: 591 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G6AVK6

References