Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-HTH_XRE
Location 2068677..2069920 Replicon chromosome
Accession NZ_CP102141
Organism Streptococcus suis strain DNR48

Toxin (Protein)


Gene name sezT Uniprot ID -
Locus tag NQZ93_RS10315 Protein ID WP_024388341.1
Coordinates 2068677..2069444 (-) Length 256 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag NQZ93_RS10320 Protein ID WP_024388340.1
Coordinates 2069444..2069920 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ93_RS10300 (NQZ93_10300) 2065063..2065428 - 366 WP_012775542.1 plasmid mobilization relaxosome protein MobC -
NQZ93_RS10305 (NQZ93_10305) 2065438..2065797 - 360 WP_012775541.1 SAG1252 family conjugative relaxosome accessory protein -
NQZ93_RS10310 (NQZ93_10310) 2066132..2068639 - 2508 WP_257115284.1 AAA family ATPase -
NQZ93_RS10315 (NQZ93_10315) 2068677..2069444 - 768 WP_024388341.1 type II toxin-antitoxin system toxin PezT Toxin
NQZ93_RS10320 (NQZ93_10320) 2069444..2069920 - 477 WP_024388340.1 type II toxin-antitoxin system antitoxin PezA Antitoxin
NQZ93_RS10325 (NQZ93_10325) 2069990..2070280 - 291 WP_000667951.1 hypothetical protein -
NQZ93_RS10330 (NQZ93_10330) 2070331..2070720 - 390 WP_000048066.1 DUF5945 family protein -
NQZ93_RS10335 (NQZ93_10335) 2070717..2070944 - 228 WP_000110922.1 DUF5965 family protein -
NQZ93_RS10340 (NQZ93_10340) 2070972..2072072 - 1101 WP_238712659.1 toprim domain-containing protein -
NQZ93_RS10345 (NQZ93_10345) 2072349..2072651 - 303 WP_172005808.1 recombinase family protein -
NQZ93_RS10350 (NQZ93_10350) 2072706..2072969 - 264 WP_000253176.1 hypothetical protein -
NQZ93_RS10355 (NQZ93_10355) 2072969..2073199 - 231 WP_001206986.1 PC4/YdbC family ssDNA-binding protein -
NQZ93_RS10360 (NQZ93_10360) 2073245..2074099 - 855 WP_000743700.1 ParB/RepB/Spo0J family partition protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island tet(O) - 2033353..2081741 48388


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(28-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 256 a.a.        Molecular weight: 28892.63 Da        Isoelectric Point: 4.9804

>T253230 WP_024388341.1 NZ_CP102141:c2069444-2068677 [Streptococcus suis]
MRLEEFSEAEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRINQKEFQGNIIVIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKIVEHLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLASKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKEHHDGIVENLVDNLRELESEKLFDQIQIYQRDKTCVYDSETDEGSAAEVLQNCLFGEWSKVEEEMM
KVGELLLNELLEKNK

Download         Length: 768 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18321.81 Da        Isoelectric Point: 4.5683

>AT253230 WP_024388340.1 NZ_CP102141:c2069920-2069444 [Streptococcus suis]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSKVSTELIDRICQKFNVSYVDIVGEDKMLAPVEDYQLTLKIE
VIKERGAAILSQLYRYQDSQDIAFDDESNPWILMSDDLAELIHTKIYLVDTFDEIERYNGYLDGIERMLEMVHHRVVA

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References