Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1359083..1359569 Replicon chromosome
Accession NZ_CP102141
Organism Streptococcus suis strain DNR48

Toxin (Protein)


Gene name relE Uniprot ID D5AGV2
Locus tag NQZ93_RS06625 Protein ID WP_011922754.1
Coordinates 1359083..1359352 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag NQZ93_RS06630 Protein ID WP_002938604.1
Coordinates 1359342..1359569 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ93_RS06605 (NQZ93_06605) 1354911..1355885 - 975 WP_002937257.1 YvcK family protein -
NQZ93_RS06610 (NQZ93_06610) 1355882..1356769 - 888 WP_002937261.1 RNase adapter RapZ -
NQZ93_RS06615 (NQZ93_06615) 1356791..1357168 - 378 WP_024381582.1 RidA family protein -
NQZ93_RS06620 (NQZ93_06620) 1357358..1358677 - 1320 WP_257115199.1 MATE family efflux transporter -
NQZ93_RS06625 (NQZ93_06625) 1359083..1359352 - 270 WP_011922754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NQZ93_RS06630 (NQZ93_06630) 1359342..1359569 - 228 WP_002938604.1 DUF6290 family protein Antitoxin
NQZ93_RS06635 (NQZ93_06635) 1359841..1361187 - 1347 WP_024383694.1 asparagine--tRNA ligase -
NQZ93_RS06640 (NQZ93_06640) 1361202..1362383 - 1182 WP_024383693.1 pyridoxal phosphate-dependent aminotransferase -
NQZ93_RS06645 (NQZ93_06645) 1362380..1362877 - 498 WP_024383692.1 DUF5590 domain-containing protein -
NQZ93_RS06650 (NQZ93_06650) 1363178..1363627 + 450 WP_024381709.1 MarR family transcriptional regulator -
NQZ93_RS06655 (NQZ93_06655) 1363690..1364235 + 546 WP_002941732.1 NADPH-dependent FMN reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10437.49 Da        Isoelectric Point: 10.3916

>T253227 WP_011922754.1 NZ_CP102141:c1359352-1359083 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT253227 WP_002938604.1 NZ_CP102141:c1359569-1359342 [Streptococcus suis]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126UKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References