Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 960710..961196 Replicon chromosome
Accession NZ_CP102141
Organism Streptococcus suis strain DNR48

Toxin (Protein)


Gene name relE Uniprot ID A0A075SGM1
Locus tag NQZ93_RS04670 Protein ID WP_024381850.1
Coordinates 960710..960967 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A075SQT6
Locus tag NQZ93_RS04675 Protein ID WP_024381851.1
Coordinates 960957..961196 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ93_RS04650 (NQZ93_04650) 956341..957411 + 1071 WP_024381847.1 tyrosine recombinase XerS -
NQZ93_RS04655 (NQZ93_04655) 957481..958989 - 1509 WP_257115375.1 phosphomannomutase/phosphoglucomutase -
NQZ93_RS04660 (NQZ93_04660) 959065..960006 - 942 WP_002935009.1 sensor histidine kinase -
NQZ93_RS04665 (NQZ93_04665) 960003..960671 - 669 WP_024381849.1 response regulator transcription factor -
NQZ93_RS04670 (NQZ93_04670) 960710..960967 - 258 WP_024381850.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NQZ93_RS04675 (NQZ93_04675) 960957..961196 - 240 WP_024381851.1 DUF6290 family protein Antitoxin
NQZ93_RS04680 (NQZ93_04680) 961286..963256 - 1971 WP_257115376.1 FtsX-like permease family protein -
NQZ93_RS04685 (NQZ93_04685) 963257..964009 - 753 WP_024381853.1 ABC transporter ATP-binding protein -
NQZ93_RS04690 (NQZ93_04690) 964018..964407 - 390 WP_024381854.1 NisI/SpaI family lantibiotic immunity lipoprotein -
NQZ93_RS04695 (NQZ93_04695) 964420..964560 - 141 WP_032505027.1 hypothetical protein -
NQZ93_RS04700 (NQZ93_04700) 964698..965864 - 1167 Protein_878 carbamoyl phosphate synthase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-75)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9854.56 Da        Isoelectric Point: 10.7134

>T253226 WP_024381850.1 NZ_CP102141:c960967-960710 [Streptococcus suis]
MSYKVILSAKAQKQIRKMDKTAASLILRYLYKHIDGCDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEDDKLIMTSIKM
RNGSI

Download         Length: 258 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8922.12 Da        Isoelectric Point: 3.8812

>AT253226 WP_024381851.1 NZ_CP102141:c961196-960957 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADRAWAEYQEDLANGIEPITLEQMAEELGIEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A075SGM1

Antitoxin

Source ID Structure
AlphaFold DB A0A075SQT6

References