Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | sezT-pezT/zeta-couple_hipB |
| Location | 1040932..1042202 | Replicon | chromosome |
| Accession | NZ_CP102140 | ||
| Organism | Streptococcus suis strain DNC49 | ||
Toxin (Protein)
| Gene name | sezT | Uniprot ID | A0A0Z8INM2 |
| Locus tag | NQZ94_RS05320 | Protein ID | WP_024409332.1 |
| Coordinates | 1040932..1041726 (-) | Length | 265 a.a. |
Antitoxin (Protein)
| Gene name | pezT | Uniprot ID | - |
| Locus tag | NQZ94_RS05325 | Protein ID | WP_024409333.1 |
| Coordinates | 1041726..1042202 (-) | Length | 159 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NQZ94_RS05300 (NQZ94_05300) | 1035960..1037885 | - | 1926 | WP_257116278.1 | ATP-dependent helicase | - |
| NQZ94_RS05305 (NQZ94_05305) | 1037882..1039711 | - | 1830 | WP_024409329.1 | AAA family ATPase | - |
| NQZ94_RS05310 (NQZ94_05310) | 1039713..1040657 | - | 945 | WP_024409330.1 | IS30 family transposase | - |
| NQZ94_RS05315 (NQZ94_05315) | 1040742..1040951 | - | 210 | WP_024409331.1 | AAA family ATPase | - |
| NQZ94_RS05320 (NQZ94_05320) | 1040932..1041726 | - | 795 | WP_024409332.1 | type II toxin-antitoxin system toxin PezT | Toxin |
| NQZ94_RS05325 (NQZ94_05325) | 1041726..1042202 | - | 477 | WP_024409333.1 | type II toxin-antitoxin system antitoxin PezA | Antitoxin |
| NQZ94_RS05330 (NQZ94_05330) | 1042272..1042556 | - | 285 | WP_024409334.1 | hypothetical protein | - |
| NQZ94_RS05335 (NQZ94_05335) | 1042600..1042995 | - | 396 | WP_017285409.1 | DUF5945 family protein | - |
| NQZ94_RS05340 (NQZ94_05340) | 1042999..1043226 | - | 228 | WP_024409335.1 | DUF5965 family protein | - |
| NQZ94_RS05345 (NQZ94_05345) | 1043280..1044368 | - | 1089 | WP_024409336.1 | toprim domain-containing protein | - |
| NQZ94_RS05350 (NQZ94_05350) | 1044408..1045046 | - | 639 | WP_024409337.1 | hypothetical protein | - |
| NQZ94_RS05355 (NQZ94_05355) | 1045157..1045447 | - | 291 | WP_024409338.1 | DUF5966 family protein | - |
| NQZ94_RS05360 (NQZ94_05360) | 1045462..1045761 | - | 300 | WP_024382151.1 | DUF5962 family protein | - |
| NQZ94_RS05365 (NQZ94_05365) | 1045831..1046778 | - | 948 | WP_226960637.1 | helicase SNF2 | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | tet(O) | - | 1019966..1080983 | 61017 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 265 a.a. Molecular weight: 30360.57 Da Isoelectric Point: 6.6151
>T253222 WP_024409332.1 NZ_CP102140:c1041726-1040932 [Streptococcus suis]
MRLEEFSKDDFDLALKRTIRSLTRGKTTSVTPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSLHPNYLTLQE
EYGKDSVDYTKGFAGKMVEQLVDELSKQGYHLLIEGTLRTTEVPRKTARLLKARGYQVSLALIATKPELSYLSTLIRYEE
VYVVNPNQARATPKEHHDGIVNHLVDNLRELENDHLFDYIQIYQRDRSCVYDSETDDGSAAEVLQECLFGKWSKVEEEMM
KMGQELLMEFLEMKKGRIYENKKN
MRLEEFSKDDFDLALKRTIRSLTRGKTTSVTPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSLHPNYLTLQE
EYGKDSVDYTKGFAGKMVEQLVDELSKQGYHLLIEGTLRTTEVPRKTARLLKARGYQVSLALIATKPELSYLSTLIRYEE
VYVVNPNQARATPKEHHDGIVNHLVDNLRELENDHLFDYIQIYQRDRSCVYDSETDDGSAAEVLQECLFGKWSKVEEEMM
KMGQELLMEFLEMKKGRIYENKKN
Download Length: 795 bp
Antitoxin
Download Length: 159 a.a. Molecular weight: 18119.46 Da Isoelectric Point: 4.3193
>AT253222 WP_024409333.1 NZ_CP102140:c1042202-1041726 [Streptococcus suis]
MIGDNIKSLRKTHDLTQPEFAKIVGISRNSLSRYENGTSSLSTELIDRICQKFNVSYVDIVGEEKMLTPVEDYQLTLKIE
VIKERGAAILSELYRYQDSQGITFDDETSPWILMSDDLSDLINTKIYLVNTFDEVERYNGYLDGIERMLELANHQVVA
MIGDNIKSLRKTHDLTQPEFAKIVGISRNSLSRYENGTSSLSTELIDRICQKFNVSYVDIVGEEKMLTPVEDYQLTLKIE
VIKERGAAILSELYRYQDSQGITFDDETSPWILMSDDLSDLINTKIYLVNTFDEVERYNGYLDGIERMLELANHQVVA
Download Length: 477 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|