Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 509046..509532 Replicon chromosome
Accession NZ_CP102140
Organism Streptococcus suis strain DNC49

Toxin (Protein)


Gene name relE Uniprot ID D5AGV2
Locus tag NQZ94_RS02715 Protein ID WP_011922754.1
Coordinates 509263..509532 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag NQZ94_RS02710 Protein ID WP_002938604.1
Coordinates 509046..509273 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ94_RS02685 (NQZ94_02685) 504378..504923 - 546 WP_009909618.1 NADPH-dependent FMN reductase -
NQZ94_RS02690 (NQZ94_02690) 504986..505435 - 450 WP_009909619.1 MarR family transcriptional regulator -
NQZ94_RS02695 (NQZ94_02695) 505738..506235 + 498 WP_002938611.1 DUF5590 domain-containing protein -
NQZ94_RS02700 (NQZ94_02700) 506232..507413 + 1182 WP_002938610.1 pyridoxal phosphate-dependent aminotransferase -
NQZ94_RS02705 (NQZ94_02705) 507428..508774 + 1347 WP_013730302.1 asparagine--tRNA ligase -
NQZ94_RS02710 (NQZ94_02710) 509046..509273 + 228 WP_002938604.1 DUF6290 family protein Antitoxin
NQZ94_RS02715 (NQZ94_02715) 509263..509532 + 270 WP_011922754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NQZ94_RS02720 (NQZ94_02720) 509938..511257 + 1320 WP_002937278.1 MATE family efflux transporter -
NQZ94_RS02725 (NQZ94_02725) 511441..511818 + 378 WP_013730303.1 RidA family protein -
NQZ94_RS02730 (NQZ94_02730) 511840..512727 + 888 WP_002937261.1 RNase adapter RapZ -
NQZ94_RS02735 (NQZ94_02735) 512724..513698 + 975 WP_002937257.1 YvcK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10437.49 Da        Isoelectric Point: 10.3916

>T253220 WP_011922754.1 NZ_CP102140:509263-509532 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT253220 WP_002938604.1 NZ_CP102140:509046-509273 [Streptococcus suis]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126UKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References