Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 2244120..2244835 Replicon chromosome
Accession NC_015588
Organism Isoptericola variabilis 225

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ISOVA_RS16125 Protein ID WP_013839202.1
Coordinates 2244386..2244835 (+) Length 150 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag ISOVA_RS16120 Protein ID WP_013839201.1
Coordinates 2244120..2244383 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISOVA_RS10455 2239456..2240517 + 1062 WP_013839198.1 cytochrome d ubiquinol oxidase subunit II -
ISOVA_RS10460 2240534..2242300 + 1767 WP_013839199.1 thiol reductant ABC exporter subunit CydD -
ISOVA_RS10465 2242287..2244116 + 1830 WP_013839200.1 thiol reductant ABC exporter subunit CydC -
ISOVA_RS16120 2244120..2244383 + 264 WP_013839201.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
ISOVA_RS16125 2244386..2244835 + 450 WP_013839202.1 type II toxin-antitoxin system VapC family toxin Toxin
ISOVA_RS10475 2244759..2245217 - 459 Protein_2069 DUF3626 domain-containing protein -
ISOVA_RS10480 2245277..2246872 - 1596 WP_013839203.1 NAD(P)/FAD-dependent oxidoreductase -
ISOVA_RS10485 2246928..2247872 + 945 WP_013839204.1 phosphoglycerate dehydrogenase -
ISOVA_RS10490 2247882..2248163 - 282 Protein_2072 DUF3995 domain-containing protein -
ISOVA_RS10495 2248455..2248652 + 198 WP_143762110.1 hypothetical protein -
ISOVA_RS10500 2248656..2249573 - 918 WP_013839206.1 bifunctional DNA-formamidopyrimidine glycosylase/DNA-(apurinic or apyrimidinic site) lyase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-119)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-41)


Sequences

Toxin        


Download         Length: 150 a.a.        Molecular weight: 16009.13 Da        Isoelectric Point: 6.6477

>T25322 WP_013839202.1 NC_015588:2244386-2244835 [Isoptericola variabilis 225]
VHYLDTSALVKLVVREPESAALKKWVDANDDRLVSSDLARTELLRAVRRAAPEHAVTARAVLDAVDLLALTTADFEAAAH
LDPDIVRSLDALHLATALRLGDELESMVTYDVRLADAARYHGVAVTAPGSPSRPRTNPARTGPAGARRT

Download         Length: 450 bp

>T25322 NC_015588:2244386-2244835 [Isoptericola variabilis 225]
GTGCACTACCTGGACACCTCGGCACTGGTGAAACTCGTCGTCAGGGAGCCAGAGTCGGCCGCGCTCAAGAAGTGGGTCGA
TGCGAACGACGATCGCCTGGTCTCCAGCGATCTCGCCCGCACCGAGCTGCTCCGGGCAGTTCGACGGGCGGCGCCGGAGC
ATGCCGTCACGGCCCGCGCGGTGCTCGATGCCGTCGACCTCCTCGCATTGACCACCGCGGACTTCGAGGCGGCGGCGCAC
CTCGACCCCGACATCGTGCGCTCCTTGGATGCTCTCCACCTCGCGACGGCCCTGCGGCTCGGTGACGAGCTGGAGTCGAT
GGTGACCTATGACGTTCGGCTGGCGGACGCCGCCCGGTACCACGGTGTAGCGGTCACCGCTCCGGGTTCGCCTTCACGAC
CGCGGACCAACCCCGCCCGAACCGGGCCAGCAGGTGCCAGACGTACTTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9219.44 Da        Isoelectric Point: 10.3691

>AT25322 WP_013839201.1 NC_015588:2244120-2244383 [Isoptericola variabilis 225]
MSTVGIRELKQNASAVVSSAAAGEVITITDRGRPVAQLSALADTVIDRLTATGQVRRAHRRMRDLPAPTAAGDVSASLAE
MRDAERY

Download         Length: 264 bp

>AT25322 NC_015588:2244120-2244383 [Isoptericola variabilis 225]
ATGAGCACCGTCGGAATCCGAGAGCTGAAGCAGAACGCCTCTGCCGTCGTGTCCTCGGCAGCGGCAGGTGAGGTCATCAC
CATCACGGACCGCGGCCGACCGGTCGCACAGTTGTCCGCCCTCGCCGATACCGTGATCGACCGACTCACGGCAACCGGTC
AGGTGCGCCGCGCCCATCGGCGAATGCGCGACCTTCCCGCACCCACCGCGGCAGGAGACGTCTCCGCATCGCTGGCGGAG
ATGCGCGACGCCGAGAGGTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References