Detailed information of TA system TA253218

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 1068285..1069717
• Replicon: chromosome
• Accession: NZ_CP102138
• Organism: Streptococcus suis strain M102942_S11

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: -
• Locus tag: NQZ95_RS05385
• Protein ID: WP_192062950.1
• Coordinates: 1068872..1069717 (+)
• Length: 282 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: -
• Locus tag: NQZ95_RS05380
• Protein ID: WP_192062951.1
• Coordinates: 1068285..1068875 (+)
• Length: 197 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NQZ95_RS05380 (NQZ95_05380)	1068285..1068875	+	591	WP_192062951.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
NQZ95_RS05385 (NQZ95_05385)	1068872..1069717	+	846	WP_192062950.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
NQZ95_RS05390 (NQZ95_05390)	1069803..1070087	-	285	Protein_1030	CHAP domain-containing protein	-
NQZ95_RS05395 (NQZ95_05395)	1070202..1071212	-	1011	WP_257105064.1	Abi family protein	-
NQZ95_RS05400 (NQZ95_05400)	1071350..1074151	-	2802	WP_257105065.1	phage tail tip lysozyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	erm(B) / tet(O)	-	1018887..1125720	106833

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-258)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (6-50)

Sequences

Toxin

Protein

• Length: 282 a.a.
• Molecular weight: 32365.01 Da
• Isoelectric Point: 5.2111

>T253218 WP_192062950.1 NZ_CP102138:1068872-1069717 [Streptococcus suis]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSTYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQITLSEE
TVKQQIEEVLADSEKGISFTIQSITAIKESDDYGGYRATILCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEDNFP
IIAYTIETILAEKLQTVYSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLKNACQRTFSYRETELDFVKIIELLERFKSAP
IQNKQWQNYSKKYSYTKGISLADVLDEMINLITIIISTDSD

Nucleotide

• Length: 846 bp

Antitoxin

Protein

• Length: 197 a.a.
• Molecular weight: 23337.90 Da
• Isoelectric Point: 7.3110

>AT253218 WP_192062951.1 NZ_CP102138:1068285-1068875 [Streptococcus suis]
MSKKEILLEFIENHNGIITYKDCKALKIPTIYLTRLEKEGIIYRVEKGIFLTQNGDYDEYYFFQYRYPKAIFSYISALYL
QQFTDEIPQYFDVTIPRGYRFNTPPENLNIHSVSKEYSELGITLVKTPMGNEVRVYDLERIICDFVIHREKIDTELFVKT
LQHYGNYSKKNLTKLYEYATKMNTLDKVKQTLEVLV

Nucleotide

• Length: 591 bp