Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 975772..976258 Replicon chromosome
Accession NZ_CP102138
Organism Streptococcus suis strain M102942_S11

Toxin (Protein)


Gene name relE Uniprot ID A0A0K2E5U8
Locus tag NQZ95_RS04890 Protein ID WP_002935012.1
Coordinates 975772..976029 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0K2E5B0
Locus tag NQZ95_RS04895 Protein ID WP_002935014.1
Coordinates 976019..976258 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ95_RS04870 (NQZ95_04870) 971406..972476 + 1071 WP_002935006.1 tyrosine recombinase XerS -
NQZ95_RS04875 (NQZ95_04875) 972546..974054 - 1509 WP_013730362.1 phosphoglucomutase -
NQZ95_RS04880 (NQZ95_04880) 974130..975071 - 942 WP_002935009.1 sensor histidine kinase -
NQZ95_RS04885 (NQZ95_04885) 975068..975733 - 666 WP_009909826.1 response regulator transcription factor -
NQZ95_RS04890 (NQZ95_04890) 975772..976029 - 258 WP_002935012.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NQZ95_RS04895 (NQZ95_04895) 976019..976258 - 240 WP_002935014.1 DUF6290 family protein Antitoxin
NQZ95_RS04900 (NQZ95_04900) 976350..978320 - 1971 WP_257105116.1 FtsX-like permease family protein -
NQZ95_RS04905 (NQZ95_04905) 978321..979073 - 753 WP_002935019.1 ABC transporter ATP-binding protein -
NQZ95_RS04910 (NQZ95_04910) 979209..979943 - 735 WP_011922410.1 ABC transporter permease -
NQZ95_RS04915 (NQZ95_04915) 979945..980691 - 747 WP_011922411.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-75)

Antitoxin

Protein of unknown function DUF6290

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9849.52 Da        Isoelectric Point: 10.7134

>T253216 WP_002935012.1 NZ_CP102138:c976029-975772 [Streptococcus suis]
MSYKVILSAKAQKQIRKMDKTAASLILRYLYKHIDGCDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8924.19 Da        Isoelectric Point: 3.9191

>AT253216 WP_002935014.1 NZ_CP102138:c976258-976019 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADVAWAEYQADLANRIEPMTLEQMAEELGIEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2E5U8

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E5B0

References