Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | omega-epsilon-zeta/zeta-couple_hipB |
| Location | 640085..641328 | Replicon | chromosome |
| Accession | NZ_CP102137 | ||
| Organism | Streptococcus suis strain M104300_S20 | ||
Toxin (Protein)
| Gene name | sezT | Uniprot ID | G7SEB4 |
| Locus tag | NQZ96_RS03180 | Protein ID | WP_001235242.1 |
| Coordinates | 640561..641328 (+) | Length | 256 a.a. |
Antitoxin (Protein)
| Gene name | sezA | Uniprot ID | - |
| Locus tag | NQZ96_RS03175 | Protein ID | WP_000578719.1 |
| Coordinates | 640085..640561 (+) | Length | 159 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NQZ96_RS03140 (NQZ96_03140) | 635465..635695 | + | 231 | WP_001206986.1 | PC4/YdbC family ssDNA-binding protein | - |
| NQZ96_RS03145 (NQZ96_03145) | 635695..635958 | + | 264 | WP_000253176.1 | hypothetical protein | - |
| NQZ96_RS03150 (NQZ96_03150) | 636013..637869 | + | 1857 | WP_001820670.1 | recombinase family protein | - |
| NQZ96_RS03155 (NQZ96_03155) | 637933..639033 | + | 1101 | WP_000196860.1 | toprim domain-containing protein | - |
| NQZ96_RS03160 (NQZ96_03160) | 639061..639288 | + | 228 | WP_000110922.1 | DUF5965 family protein | - |
| NQZ96_RS03165 (NQZ96_03165) | 639285..639674 | + | 390 | WP_000048066.1 | DUF5945 family protein | - |
| NQZ96_RS03170 (NQZ96_03170) | 639725..640015 | + | 291 | WP_000667951.1 | hypothetical protein | - |
| NQZ96_RS03175 (NQZ96_03175) | 640085..640561 | + | 477 | WP_000578719.1 | type II toxin-antitoxin system antitoxin PezA | Antitoxin |
| NQZ96_RS03180 (NQZ96_03180) | 640561..641328 | + | 768 | WP_001235242.1 | type II toxin-antitoxin system toxin PezT | Toxin |
| NQZ96_RS03185 (NQZ96_03185) | 641329..643872 | + | 2544 | WP_000601012.1 | AAA family ATPase | - |
| NQZ96_RS03190 (NQZ96_03190) | 644210..644572 | + | 363 | WP_000140674.1 | SAG1252 family conjugative relaxosome accessory protein | - |
| NQZ96_RS03195 (NQZ96_03195) | 644575..644940 | + | 366 | WP_000431640.1 | MobC family plasmid mobilization relaxosome protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 256 a.a. Molecular weight: 28985.80 Da Isoelectric Point: 5.1126
>T253210 WP_001235242.1 NZ_CP102137:640561-641328 [Streptococcus suis]
MRLEEFSEAEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEQLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKEHHDGIVENLVDNLRELESENLFDQIQIYQRDRTCIYDSETAEGSAAEVLQECLFGKWSKVEEEMV
KESELLLKELLEKNK
MRLEEFSEAEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEQLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKEHHDGIVENLVDNLRELESENLFDQIQIYQRDRTCIYDSETAEGSAAEVLQECLFGKWSKVEEEMV
KESELLLKELLEKNK
Download Length: 768 bp
Antitoxin
Download Length: 159 a.a. Molecular weight: 18266.77 Da Isoelectric Point: 4.6424
>AT253210 WP_000578719.1 NZ_CP102137:640085-640561 [Streptococcus suis]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYHLTLKVE
VIKERGAAILSKLYRYQDSQDIVFDDESNPWILMSDDLAELINTKIYLVATFDEIERYNGYLDGIERMLDMVHHRVVA
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYHLTLKVE
VIKERGAAILSKLYRYQDSQDIVFDDESNPWILMSDDLAELINTKIYLVATFDEIERYNGYLDGIERMLDMVHHRVVA
Download Length: 477 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|