Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 724337..725006 Replicon chromosome
Accession NZ_CP102136
Organism Streptococcus suis strain M105052_S26

Toxin (Protein)


Gene name hicA Uniprot ID G7SGM1
Locus tag NQZ97_RS03710 Protein ID WP_014637653.1
Coordinates 724337..724519 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0M9FH26
Locus tag NQZ97_RS03715 Protein ID WP_029180323.1
Coordinates 724557..725006 (+) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ97_RS03685 (NQZ97_03685) 719774..719923 + 150 WP_012775228.1 50S ribosomal protein L33 -
NQZ97_RS03690 (NQZ97_03690) 719970..720203 + 234 WP_002935768.1 preprotein translocase subunit SecG -
NQZ97_RS03695 (NQZ97_03695) 720635..723004 + 2370 WP_256787602.1 ribonuclease R -
NQZ97_RS03700 (NQZ97_03700) 723007..723474 + 468 WP_002935771.1 SsrA-binding protein SmpB -
NQZ97_RS03705 (NQZ97_03705) 723752..724006 + 255 WP_105157913.1 hypothetical protein -
NQZ97_RS03710 (NQZ97_03710) 724337..724519 + 183 WP_014637653.1 type II toxin-antitoxin system HicA family toxin Toxin
NQZ97_RS03715 (NQZ97_03715) 724557..725006 + 450 WP_029180323.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NQZ97_RS03720 (NQZ97_03720) 725167..726210 - 1044 WP_174850212.1 alcohol dehydrogenase catalytic domain-containing protein -
NQZ97_RS03725 (NQZ97_03725) 726364..727224 + 861 WP_174850210.1 SAM-dependent methyltransferase TehB -
NQZ97_RS03730 (NQZ97_03730) 727313..729166 + 1854 WP_170238434.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 665591..729166 63575


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6653.87 Da        Isoelectric Point: 10.8207

>T253205 WP_014637653.1 NZ_CP102136:724337-724519 [Streptococcus suis]
MPMTQKEMVKLLTAHGWTKTKGGKGSHVKLEKAGERPITIPHGEINKYTERGIKKQAGLL

Download         Length: 183 bp

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16638.66 Da        Isoelectric Point: 4.0193

>AT253205 WP_029180323.1 NZ_CP102136:724557-725006 [Streptococcus suis]
MLVTYPALFYFDDTDGANAPYFVTFPDFEHSATQGEDMADAMAMASDWLGMNLADYIENGRDIPTPSSINTLSLVDNNPF
RNEDFEMVYDSSKSFISMVMVDVAKYLGSQEPVKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKIHA

Download         Length: 450 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G7SGM1

Antitoxin

Source ID Structure
AlphaFold DB A0A0M9FH26

References