253204

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-HTH_XRE
Location 298207..299468 Replicon chromosome
Accession NZ_CP102136
Organism Streptococcus suis strain M105052_S26

Toxin (Protein)


Gene name sezT Uniprot ID -
Locus tag NQZ97_RS01480 Protein ID WP_256787580.1
Coordinates 298683..299468 (+) Length 262 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag NQZ97_RS01475 Protein ID WP_256787581.1
Coordinates 298207..298683 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ97_RS01440 (NQZ97_01440) 293418..293744 - 327 WP_002937550.1 PadR family transcriptional regulator -
NQZ97_RS01445 (NQZ97_01445) 294038..294418 + 381 WP_043025465.1 CidA/LrgA family protein -
NQZ97_RS01450 (NQZ97_01450) 294411..295106 + 696 WP_043025463.1 LrgB family protein -
NQZ97_RS01455 (NQZ97_01455) 295140..295940 - 801 WP_257110628.1 formate/nitrite transporter family protein -
NQZ97_RS01460 (NQZ97_01460) 296080..296925 + 846 WP_043025461.1 MIP/aquaporin family protein -
NQZ97_RS01465 (NQZ97_01465) 297057..297215 + 159 Protein_256 DUF853 domain-containing protein -
NQZ97_RS01470 (NQZ97_01470) 297345..297959 + 615 WP_257110629.1 CoA pyrophosphatase -
NQZ97_RS01475 (NQZ97_01475) 298207..298683 + 477 WP_256787581.1 type II toxin-antitoxin system antitoxin PezA Antitoxin
NQZ97_RS01480 (NQZ97_01480) 298683..299468 + 786 WP_256787580.1 type II toxin-antitoxin system toxin PezT Toxin
NQZ97_RS01485 (NQZ97_01485) 299487..300926 + 1440 WP_256787579.1 AbiH family protein -
NQZ97_RS01490 (NQZ97_01490) 301173..302336 - 1164 WP_257110630.1 IS30 family transposase -
NQZ97_RS01495 (NQZ97_01495) 302546..302938 + 393 WP_256787783.1 ImmA/IrrE family metallo-endopeptidase -
NQZ97_RS01500 (NQZ97_01500) 302928..303131 + 204 WP_033875445.1 hypothetical protein -
NQZ97_RS01505 (NQZ97_01505) 303264..304031 + 768 WP_172108257.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 301173..302336 1163


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(28-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 262 a.a.        Molecular weight: 29614.50 Da        Isoelectric Point: 6.2500

>T253204 WP_256787580.1 NZ_CP102136:298683-299468 [Streptococcus suis]
MRLEEFSEAGFQKALQRTIRALTRGKTIPGQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEHLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLVSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPNQARATPKEHHDGIVENLVDNLRELEREQLFDQIQIYQRDRTCIYDSKTDDGSAAEVLQNCLFGEWSKVEEEMF
KMGQERLRELSKSNGNDVLMS

Download         Length: 786 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18306.79 Da        Isoelectric Point: 4.5591

>AT253204 WP_256787581.1 NZ_CP102136:298207-298683 [Streptococcus suis]
MIGENIKTLRHTHDLTQPEFAKMVGISRNSLSRYENGTSKISTELIDRICQKFNVSYVDIVGEEKMLAPVEDYQLTLKVE
VIKERGAAILSQLYRYQDSQNIAFDDESNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLDMVHHRVVA

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References