Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | omega-epsilon-zeta/zeta-couple_hipB |
| Location | 1013167..1014410 | Replicon | chromosome |
| Accession | NZ_CP102135 | ||
| Organism | Streptococcus suis strain M106471_S40 | ||
Toxin (Protein)
| Gene name | sezT | Uniprot ID | G7SEB4 |
| Locus tag | NQZ98_RS05180 | Protein ID | WP_001235242.1 |
| Coordinates | 1013167..1013934 (-) | Length | 256 a.a. |
Antitoxin (Protein)
| Gene name | sezA | Uniprot ID | - |
| Locus tag | NQZ98_RS05185 | Protein ID | WP_000578719.1 |
| Coordinates | 1013934..1014410 (-) | Length | 159 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NQZ98_RS05165 (NQZ98_05165) | 1009555..1009920 | - | 366 | WP_000431640.1 | MobC family plasmid mobilization relaxosome protein | - |
| NQZ98_RS05170 (NQZ98_05170) | 1009923..1010285 | - | 363 | WP_000140674.1 | SAG1252 family conjugative relaxosome accessory protein | - |
| NQZ98_RS05175 (NQZ98_05175) | 1010623..1013166 | - | 2544 | WP_000601012.1 | AAA family ATPase | - |
| NQZ98_RS05180 (NQZ98_05180) | 1013167..1013934 | - | 768 | WP_001235242.1 | type II toxin-antitoxin system toxin PezT | Toxin |
| NQZ98_RS05185 (NQZ98_05185) | 1013934..1014410 | - | 477 | WP_000578719.1 | type II toxin-antitoxin system antitoxin PezA | Antitoxin |
| NQZ98_RS05190 (NQZ98_05190) | 1014480..1014770 | - | 291 | WP_000667951.1 | hypothetical protein | - |
| NQZ98_RS05195 (NQZ98_05195) | 1014826..1015380 | + | 555 | Protein_977 | rRNA adenine N-6-methyltransferase family protein | - |
| NQZ98_RS05200 (NQZ98_05200) | 1015550..1015810 | + | 261 | Protein_978 | topoisomerase DNA-binding C4 zinc finger domain-containing protein | - |
| NQZ98_RS05205 (NQZ98_05205) | 1015839..1016000 | - | 162 | Protein_979 | recombinase | - |
| NQZ98_RS05210 (NQZ98_05210) | 1016055..1016318 | - | 264 | WP_000253176.1 | hypothetical protein | - |
| NQZ98_RS05215 (NQZ98_05215) | 1016318..1016548 | - | 231 | WP_001206986.1 | PC4/YdbC family ssDNA-binding protein | - |
| NQZ98_RS05220 (NQZ98_05220) | 1016594..1017448 | - | 855 | WP_000743700.1 | ParB/RepB/Spo0J family partition protein | - |
| NQZ98_RS05225 (NQZ98_05225) | 1017457..1018410 | - | 954 | WP_257116693.1 | MobV family relaxase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | tet(O) | - | 948050..1033903 | 85853 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 256 a.a. Molecular weight: 28985.80 Da Isoelectric Point: 5.1126
>T253201 WP_001235242.1 NZ_CP102135:c1013934-1013167 [Streptococcus suis]
MRLEEFSEAEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEQLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKEHHDGIVENLVDNLRELESENLFDQIQIYQRDRTCIYDSETAEGSAAEVLQECLFGKWSKVEEEMV
KESELLLKELLEKNK
MRLEEFSEAEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEQLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKEHHDGIVENLVDNLRELESENLFDQIQIYQRDRTCIYDSETAEGSAAEVLQECLFGKWSKVEEEMV
KESELLLKELLEKNK
Download Length: 768 bp
Antitoxin
Download Length: 159 a.a. Molecular weight: 18266.77 Da Isoelectric Point: 4.6424
>AT253201 WP_000578719.1 NZ_CP102135:c1014410-1013934 [Streptococcus suis]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYHLTLKVE
VIKERGAAILSKLYRYQDSQDIVFDDESNPWILMSDDLAELINTKIYLVATFDEIERYNGYLDGIERMLDMVHHRVVA
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYHLTLKVE
VIKERGAAILSKLYRYQDSQDIVFDDESNPWILMSDDLAELINTKIYLVATFDEIERYNGYLDGIERMLDMVHHRVVA
Download Length: 477 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|