Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 985695..986196 Replicon chromosome
Accession NZ_CP102135
Organism Streptococcus suis strain M106471_S40

Toxin (Protein)


Gene name relE Uniprot ID A0A0M9FF45
Locus tag NQZ98_RS05020 Protein ID WP_024405694.1
Coordinates 985695..985961 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A116MIY1
Locus tag NQZ98_RS05025 Protein ID WP_044759715.1
Coordinates 985945..986196 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ98_RS05000 (NQZ98_05000) 981326..982396 + 1071 WP_044689537.1 tyrosine recombinase XerS -
NQZ98_RS05005 (NQZ98_05005) 982466..983974 - 1509 WP_257116686.1 phosphomannomutase/phosphoglucomutase -
NQZ98_RS05010 (NQZ98_05010) 984050..984991 - 942 WP_257116687.1 sensor histidine kinase -
NQZ98_RS05015 (NQZ98_05015) 984988..985653 - 666 WP_257116688.1 response regulator transcription factor -
NQZ98_RS05020 (NQZ98_05020) 985695..985961 - 267 WP_024405694.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NQZ98_RS05025 (NQZ98_05025) 985945..986196 - 252 WP_044759715.1 DUF6290 family protein Antitoxin
NQZ98_RS05030 (NQZ98_05030) 986544..988514 - 1971 WP_257116689.1 FtsX-like permease family protein -
NQZ98_RS05035 (NQZ98_05035) 988515..989267 - 753 WP_029173099.1 ABC transporter ATP-binding protein -
NQZ98_RS05040 (NQZ98_05040) 989276..989665 - 390 WP_257116690.1 NisI/SpaI family lantibiotic immunity lipoprotein -
NQZ98_RS05045 (NQZ98_05045) 989678..989818 - 141 WP_044773499.1 hypothetical protein -
NQZ98_RS05050 (NQZ98_05050) 989917..990354 - 438 WP_257116691.1 TraX family protein -
NQZ98_RS05055 (NQZ98_05055) 990402..990641 - 240 WP_257116692.1 hypothetical protein -
NQZ98_RS05060 (NQZ98_05060) 990654..990791 - 138 WP_002935027.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(O) - 948050..1033903 85853


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-87)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10392.08 Da        Isoelectric Point: 10.6122

>T253200 WP_024405694.1 NZ_CP102135:c985961-985695 [Streptococcus suis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEDDKLIVTALEV
GHRKEIYK

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9295.52 Da        Isoelectric Point: 3.6767

>AT253200 WP_044759715.1 NZ_CP102135:c986196-985945 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALAEYEADLANGIEPISWEEMLEELGLTDE
DLL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M9FF45

Antitoxin

Source ID Structure
AlphaFold DB A0A116MIY1

References